{"id":21169,"date":"2018-03-09T09:10:49","date_gmt":"2018-03-09T09:10:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vivo-del-papel-de-cdk4-en-el-control-de-la-proliferacion-celular\/"},"modified":"2018-03-09T09:10:49","modified_gmt":"2018-03-09T09:10:49","slug":"estudio-in-vivo-del-papel-de-cdk4-en-el-control-de-la-proliferacion-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-in-vivo-del-papel-de-cdk4-en-el-control-de-la-proliferacion-celular\/","title":{"rendered":"Estudio in vivo del papel de cdk4 en el control de la proliferaci\u00f3n celular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Mart\u00edn Gonz\u00e1lez <\/strong><\/h2>\n<p>Esta tesis tien como objetivo describir en el papel de cdk4 en el control del ciclo celular bas\u00e1ndose en el estudio de dos estirpes de rat\u00f3n cuyo genoma ha sido modificado en el gen de la quinasa cdk4: el rat\u00f3n cdk4neo\/neo (knockout funcional de cdk4) y el rat\u00f3n cdk4r24c\/r24c (knockin que expresa la quinasa mutante cdk4r24c, insensible a los inhibidores de la familia ink4).  cdk4 ejerce su funci\u00f3n al inicio del ciclo celular dirigiendo la progresi\u00f3n de la c\u00e9lula a trav\u00e9s de la fase g1 temprana del ciclo. El rat\u00f3n deificiente en esta quinasa es viable pero muestra una reducci\u00f3n de tama\u00f1o de hasta el 50%, esterilidad total en las hembras y parcial en los machos, y desarrolla diabetes debido a una reducci\u00f3n en el n\u00famero de c\u00e9lulas beta, productoras de insulina. El rat\u00f3n r24c es f\u00e9rtil y de tama\u00f1o normal pero muestra hiperplasia de los islotes endocrinos pancre\u00e1ticos.  se ha estudiado en detalle el fenotipo en c\u00e9lulas beta y se ha podido determinar que esta quinasa est\u00e1 dirigiendo el programa proliferativo de este tipo celular desde el desarrollo embrionario tard\u00edo, sin embargo no es necesaria para los procesos de neogenesis. Tambi\u00e9n se ha descrito que las c\u00e9lulas beta son especialmente sensibles a las mutaciones en cdk4 ya que no expresan cdk6, una quinasa altamente relacionada estructural y funcionalmente con cdk4.  un rescate gen\u00e9tico de la diabetes de estos animales mediante reexpresi\u00f3n de cdk4 en las c\u00e9lulas beta del rat\u00f3n deficiente confirma estos hechos.  adem\u00e1s la deficiencia causa defectos en el desarrollo de las c\u00e9lulas productoras de prolactina en la adenohip\u00f3fisis y esto es la causa de la esterilidad en las hembras. Esto queda tambi\u00e9n demostrado al reexpresar cdk4 en la adenohip\u00f3fisis del rat\u00f3n deficiente y restaurante la fertilidad.  sin embargo, a\u00fan recuperando en el entorno homornal en el rat\u00f3n cdk4neo\/neo, este sigue exhibiendo la misma reducci\u00f3n el tama\u00f1o lo que permite adjudicar a cd<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio in vivo del papel de cdk4 en el control de la proliferaci\u00f3n celular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio in vivo del papel de cdk4 en el control de la proliferaci\u00f3n celular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Mart\u00edn Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Barbacid Montalb\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Avila de grado <\/li>\n<li> Zubiaga elordieta Ana Mar\u00eda (vocal)<\/li>\n<li>eugenio Miguel angel Santos de dios (vocal)<\/li>\n<li>ramon Gomis de barbar? (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Mart\u00edn Gonz\u00e1lez Esta tesis tien como objetivo describir en el papel de cdk4 en el control [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[57650,64025,3041,42609,1375,64026],"class_list":["post-21169","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-eugenio-miguel-angel-santos-de-dios","tag-javier-martin-gonzalez","tag-jesus-avila-de-grado","tag-maria-no-barbacid-montalban","tag-ramon-gomis-de-barbar","tag-zubiaga-elordieta-ana-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21169"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21169\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}