{"id":21194,"date":"2018-03-09T09:10:52","date_gmt":"2018-03-09T09:10:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interaccion-entre-los-factores-de-transcripcion-de-drosophila-gaga-y-tramtrack\/"},"modified":"2018-03-09T09:10:52","modified_gmt":"2018-03-09T09:10:52","slug":"estudio-de-la-interaccion-entre-los-factores-de-transcripcion-de-drosophila-gaga-y-tramtrack","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-interaccion-entre-los-factores-de-transcripcion-de-drosophila-gaga-y-tramtrack\/","title":{"rendered":"Estudio de la interacci\u00f3n entre los factores de transcripci\u00f3n de drosophila gaga y tramtrack"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sara Pagans Lista <\/strong><\/h2>\n<p>Los factores de transcripci\u00f3n de drosophila gaga y tramtrack (ttk) tienen en com\u00fan la presencia de un dominio n-terminal de tipo poz\/btb, un motivo estructural muy conservado que media interacciones prote\u00edna-prote\u00edna espec\u00edficas. en este trabajo se ha demostrado que las isoformas gaga519 y ttk69 interaciconan tanto in vitro como in vivo, en levaduras y en c\u00e9lulas de drosophila schneider sl2, y que sus dominios poz\/btb son necesarios y suficientes para que esta interacci\u00f3n tenga lugar.  como muchos promotores de drosophila, la regi\u00f3n reguladora even-skipped (eve) stripe 2 contiene algunos sitios de uni\u00f3n para gaga y ttk relativamente cercanos. Mediante experimentos de transfecci\u00f3n transitoria en c\u00e9lulas sl2 se ha observado que gaga activa la transcripci\u00f3n del promotor eve stripe 2 y que ttk inhibe esta activaci\u00f3n mediada por gag. La represi\u00f3n por ttk del promotor eve requiere de la activaci\u00f3n por gaga y depende de la presencia de ambos dominios poz de ttk y gaga, sugiriendo que esta represi\u00f3n es una consecuencia de la interacci\u00f3n gaga-ttk.  interesantemente, el dominio poz de ttk es capaz de reprimir por s\u00ed solo la activaci\u00f3n mediada por gaga, mientras que la regi\u00f3n c-terminal de ttk, que contiene la secuencia consenso p-dls de uni\u00f3n al corepresor dctbp, no es necesaria para una represi\u00f3n eficiente.  consistente con esas observaciones, la substituci\u00f3n del dominio poz de gaga por el poz de ttk suprime por completo la capacidad transactivadora de gaga y convierte la prote\u00edna de fusi\u00f3n poz ttk pozgaga en un represor de la activaci\u00f3n de gaga. Por otro lado, la represi\u00f3n de ttk no parece involucrar un reclutamiento de desacetilasas, ya que la presencia de tsa no tiene ning\u00fan efecto sobre la actividad de ttk.  utilizando deleciones del promotor eve stripe 2, se ha observado que la represi\u00f3n por ttk pueden tener lugar en ausencia de lugares ttk al promotor, indicando que esta represi\u00f3n no requiere uni\u00f3n directa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la interacci\u00f3n entre los factores de transcripci\u00f3n de drosophila gaga y tramtrack<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la interacci\u00f3n entre los factores de transcripci\u00f3n de drosophila gaga y tramtrack <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sara Pagans Lista <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ferran Azorin Marin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Beato del rosal <\/li>\n<li>jordi Bernu\u00e9s mart\u00ednez (vocal)<\/li>\n<li>Francisco Antequera m\u00e1quez (vocal)<\/li>\n<li>m. lLuisa Espin\u00e1s janer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sara Pagans Lista Los factores de transcripci\u00f3n de drosophila gaga y tramtrack (ttk) tienen en com\u00fan la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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