{"id":21213,"date":"2018-03-09T09:10:53","date_gmt":"2018-03-09T09:10:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/clonacion-y-caracterizacion-de-los-genes-iniciales-de-la-ruta-biosintetica-de-la-homoserina-el-precursor-de-la-aminoetoxivinilglicina-un-inhibidor-de-la-etileno-sintetasa-de-plantas\/"},"modified":"2018-03-09T09:10:53","modified_gmt":"2018-03-09T09:10:53","slug":"clonacion-y-caracterizacion-de-los-genes-iniciales-de-la-ruta-biosintetica-de-la-homoserina-el-precursor-de-la-aminoetoxivinilglicina-un-inhibidor-de-la-etileno-sintetasa-de-plantas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/leon\/clonacion-y-caracterizacion-de-los-genes-iniciales-de-la-ruta-biosintetica-de-la-homoserina-el-precursor-de-la-aminoetoxivinilglicina-un-inhibidor-de-la-etileno-sintetasa-de-plantas\/","title":{"rendered":"Clonaci\u00f3n y caracterizaci\u00f3n de los genes iniciales de la ruta biosint\u00e9tica de la homoserina, el precursor de la aminoetoxivinilglicina, un inhibidor de la etileno sintetasa de plantas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yolanda Cuadrado L\u00f3pez <\/strong><\/h2>\n<p>Por analog\u00eda con la formaci\u00f3n de rizobitoxina en burkholderia andropogonis (michell y frey, 1988), la bios\u00edntesis de avg en streptomyces sp. Nrrl 5331 deber\u00eda seguir una ruta equivalente, derivando del \u00e1cido asp\u00e1rtico y siendo la homnoserina un intermediario esencial, como ocurre en la bios\u00edntesis de la tronina, la metionina y la isoleucina.  los genes que codifican para ask y asd han sido clonados y caracterizados en streptomyces sp. Nrrl 5331, encontr\u00e1ndose juntos (solapan en cuatro nucle\u00f3tidos) formando un oper\u00f3n.  se han observado una relaci\u00f3n directa entre el n\u00famero de copias del gen ask y el incremento observado en la producci\u00f3n de avg. As\u00ed, el transformante con una copia extra del gen ask produjo un 30% m\u00e1s de avg que la cepa control, mientras que el transformante con el gen ask en alto n\u00famero de copias y el transformante con los genes ask y asd sobreexpresados produjeron un 250% y un 300% m\u00e1s de avg que la cepa parental, respectivamente.  la actividad enzim\u00e1ca de la ask streptomyces sp. Nrrl 5331 es fuertemente estimulada por lisina e inhibida en un 30% por meso -2,6-diaminopim\u00e9lico a concentraciones altas (20 mm). El resto de amino\u00e1cidos (treonina, metionina, isoleucina, homoserina o avg) no ejercen ning\u00fan tipo de efecto ni individualmente ni concertados sobre la actividad aspartoquinasa. La s\u00edntesis de aspartoquinasa en streptomyces sp. Nrrl 5331 es fuertemente reprimida a concentraciones bajas de metionina (5 mm), ligeramente reprimida a altas concentraciones de isoleucina (20 mm) y de dap (20 mm).  existe una relaci\u00f3n clara entre la regulaci\u00f3n de aspartoquinasa y la producci\u00f3n de aminoetyoxivinilglicina. As\u00ed, se ha detectado una disminuci\u00f3n del 30% en la producci\u00f3n de aminoetoxivinilglicina cunado se creci\u00f3 streptomyces sp. Nrrl 5331 en medio m\u00ednimo con dap 20 mm, concentraci\u00f3n a la cual se detecta un 28% de inhibici\u00f3n de la actividad y un 30% de represi\u00f3n en la s\u00edntesis de la aspartoquinas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Clonaci\u00f3n y caracterizaci\u00f3n de los genes iniciales de la ruta biosint\u00e9tica de la homoserina, el precursor de la aminoetoxivinilglicina, un inhibidor de la etileno sintetasa de plantas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Clonaci\u00f3n y caracterizaci\u00f3n de los genes iniciales de la ruta biosint\u00e9tica de la homoserina, el precursor de la aminoetoxivinilglicina, un inhibidor de la etileno sintetasa de plantas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yolanda Cuadrado L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Mart\u00edn Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: paloma Liras pad\u00edn <\/li>\n<li>Juan Soliveri carranza (vocal)<\/li>\n<li>Jes\u00fas S\u00e1nchez mart\u00edn (vocal)<\/li>\n<li>Jos\u00e9 Manuel Fern\u00e1ndez \u00e1balos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yolanda Cuadrado L\u00f3pez Por analog\u00eda con la formaci\u00f3n de rizobitoxina en burkholderia andropogonis (michell y frey, 1988), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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