{"id":21225,"date":"2018-03-09T09:10:54","date_gmt":"2018-03-09T09:10:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-evaluacion-de-microesferas-de-antibioticos-aminoglucosidos\/"},"modified":"2018-03-09T09:10:54","modified_gmt":"2018-03-09T09:10:54","slug":"desarrollo-y-evaluacion-de-microesferas-de-antibioticos-aminoglucosidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/desarrollo-y-evaluacion-de-microesferas-de-antibioticos-aminoglucosidos\/","title":{"rendered":"Desarrollo y evaluaci\u00f3n de microesferas de antibi\u00f3ticos aminogluc\u00f3sidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Benjamin Santos Lobo <\/strong><\/h2>\n<p>El objetivo de la tesis era desarrollar y evaluar sistemas portadores de antibi\u00f3ticos aminogluc\u00f3sidos utilizando microesferas a base de pol\u00edmeros biocompatibles y biodegradables.  con este tipo de de vectores se pretend\u00eda conseguir la optimizaci\u00f3n en el comportamiento farmacocin\u00e9tico de estos antibi\u00f3ticos que conduzca a una reducci\u00f3n en la potencial toxicidad de estos f\u00e1rmacos sin comprometer su eficacia terap\u00e9utica.  para ello se optimiz\u00f3 un m\u00e9todo de preparaci\u00f3n de microsferas conteniendo amicacina empleando como pol\u00edmero formador de la cubierta poli-glic\u00f3lico (plaga), utilizando la t\u00e9cnica de emulsificaci\u00f3n\/evaporaci\u00f3n del solvente. una vez preparadas las microesferas se caracterizo su morfolog\u00eda, tama\u00f1o de part\u00edcula, contenido en principio activo, estabilidad y cin\u00e9tica de liberaci\u00f3n \u00abin vitro\u00bb.  el estudio \u00abin vivo\u00bb en animales de experimentaci\u00f3n de las modificaciones en la farmacocin\u00e9tica y en la distribuci\u00f3n tisular de amicacina ha permitido caracterizar la lenta liberaci\u00f3n \u00abin vivo\u00bb del f\u00e1rmaco as\u00ed como los cambios en el perfil farmacocin\u00e9tico cuando se administra este sistema portador. adem\u00e1s, la administraci\u00f3n de amicacina por v\u00eda subcut\u00e1nea incorporada en microsferas induce modificaciones en la cin\u00e9tica del f\u00e1rmaco en corteza y m\u00e9dula renal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y evaluaci\u00f3n de microesferas de antibi\u00f3ticos aminogluc\u00f3sidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y evaluaci\u00f3n de microesferas de antibi\u00f3ticos aminogluc\u00f3sidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Benjamin Santos Lobo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Martinez Lanao<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>alfonso Romero vidal (vocal)<\/li>\n<li>gloria Frutos cabanillas (vocal)<\/li>\n<li> Oliva gimena Jos\u00e9 ignacio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Benjamin Santos Lobo El objetivo de la tesis era desarrollar y evaluar sistemas portadores de antibi\u00f3ticos aminogluc\u00f3sidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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