{"id":21243,"date":"2018-03-09T09:10:56","date_gmt":"2018-03-09T09:10:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-factor-vii-de-coagulacion-en-pacientes-con-hepatitis-cronicas-mecanismos-moleculares-de-la-inhibicion-mediada-por-tgf-beta1-y-oxido-na%c2%adtrico\/"},"modified":"2018-03-09T09:10:56","modified_gmt":"2018-03-09T09:10:56","slug":"expresion-del-factor-vii-de-coagulacion-en-pacientes-con-hepatitis-cronicas-mecanismos-moleculares-de-la-inhibicion-mediada-por-tgf-beta1-y-oxido-na%c2%adtrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-factor-vii-de-coagulacion-en-pacientes-con-hepatitis-cronicas-mecanismos-moleculares-de-la-inhibicion-mediada-por-tgf-beta1-y-oxido-na%c2%adtrico\/","title":{"rendered":"Expresi\u00f3n del factor vii de coagulaci\u00f3n en pacientes con hepatitis cr\u00f3nicas. mecanismos moleculares de la inhibici\u00f3n mediada por tgf-beta1 y oxido n\u00edtrico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana De Lucas Arias <\/strong><\/h2>\n<p>Los pacientes con enfermedades hep\u00e1ticas avanzadas presentan problemas en la coagulaci\u00f3, ya que la mayor\u00eda de los factores de coagulaci\u00f3n se sintetizan en el h\u00edgado. Dentro de los factores de coagulaci\u00f3n, los niveles del factor vii, que es el encargado de iniciar las cascada extr\u00ednseca de coagulaci\u00f3n, son los primeros a disminuir.  esta ca\u00edda se ha asociado a la p\u00e9rdida neta de masa hep\u00e1tica que se produce durante la progresi\u00f3n de la enfermedad. Sin embargo, existen pacientes con cirrosis hep\u00e1tica que presentan unos niveles de factor vii inferiores a lo que se esperar\u00eda bas\u00e1ndose en su grado de funcionalidad hep\u00e1tica. este hecho sugiere que podr\u00eda existir alg\u00fan factor o factores asociados a la progresi\u00f3n de la lesi\u00f3n hep\u00e1tica que afectan directamente a la expresi\u00f3n de dicho gen. Por este motivo, se analizaron mediante hibridaci\u00f3n in situ las biopsias hep\u00e1ticas de pacientes con distinto grado de fibrosis, observ\u00e1ndose que se produce una inhibici\u00f3n progresiva de la expresi\u00f3n del gen del factor vii a medida que progresa la fibrosis.  teniendo en cuenta que durante la inflamaci\u00f3n hep\u00e1tica cr\u00f3nica se producen altos niveles de tfg-beta1 y se induce la expresi\u00f3n de la \u00f3xido n\u00edtrico sintasa inducible, con el consiguiente aumento de la producci\u00f3n de no, se dicidi\u00f3 estudiar el papel que ten\u00edan estos dos agentes en la inhibici\u00f3n progresiva del gen del fvii. As\u00ed, el tratamiento de la l\u00ednea celular de hepatoblastoma humano hepg2 bien con tgf-beta1, o bien con el donante de no s-nitroso-n-acetil-penicilamina (snap) mostr\u00f3 que ambas mol\u00e9culas eran capaces de disminuir los niveles de arnm del factor vii. Mediante transfecciones transitorias con un pl\u00e1smido que conten\u00eda un fragmento del promotor del gen del factor vii capaz de dirigir la expresi\u00f3n de un gen heter\u00f3logo a niveles similares a los del promotor completo (ya que conten\u00eda los sitios de uni\u00f3n para dos factores de transcripci\u00f3n, sp1 y hnf-4alfa esenc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n del factor vii de coagulaci\u00f3n en pacientes con hepatitis cr\u00f3nicas. mecanismos moleculares de la inhibici\u00f3n mediada por tgf-beta1 y oxido n\u00edtrico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n del factor vii de coagulaci\u00f3n en pacientes con hepatitis cr\u00f3nicas. mecanismos moleculares de la inhibici\u00f3n mediada por tgf-beta1 y oxido n\u00edtrico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana De Lucas Arias <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Carre\u00f1o Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cecilio Gimenez martin <\/li>\n<li>joaqu\u00edn D\u00edaz mediavilla (vocal)<\/li>\n<li>Jos\u00e9 Luis Bella sombria (vocal)<\/li>\n<li>Elena Rodr\u00edguez i\u00f1igo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana De Lucas Arias Los pacientes con enfermedades hep\u00e1ticas avanzadas presentan problemas en la coagulaci\u00f3, ya que 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