{"id":21259,"date":"2018-03-09T09:10:57","date_gmt":"2018-03-09T09:10:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expressio-i-regulacio-dels-transportadors-de-monosacarids-intestinals-i-renals\/"},"modified":"2018-03-09T09:10:57","modified_gmt":"2018-03-09T09:10:57","slug":"expressio-i-regulacio-dels-transportadors-de-monosacarids-intestinals-i-renals","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/expressio-i-regulacio-dels-transportadors-de-monosacarids-intestinals-i-renals\/","title":{"rendered":"Expressi\u00f3 i regulaci\u00f3 dels transportadors de monosac\u00e1rids intestinals i renals"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Barfull Font <\/strong><\/h2>\n<p>En esta tesis se ha estudiado la adaptaci\u00f3n de los transportadores de monosac\u00e1ridos intestinales y renales a distintas situaciones fisiol\u00f3gicas y fisiopatol\u00f3gicas como: desarrollo, regionalizaci\u00f3n del transporte en el intestino, adaptaci\u00f3n a ingestas como contenido variable de na+ y la adaptaci\u00f3n a la hipertensi\u00f3n arterial.  previamente se hab\u00eda descrito c\u00f3mo el transporte de monosac\u00e1ridos a trav\u00e9s de los epitelios intestinal y renal se modula y se adapta a la nueva situaci\u00f3n mediante cambios en su capacidad de transporte.  la realizaci\u00f3n del trabajo ha permitido poner a punto las t\u00e9cnicas de aislamiento de rna mensajero y northern blot para obtener un protocolo que resulte en soluciones de rna con baja contaminaci\u00f3n por prote\u00ednas y dna gen\u00f3mico, partiendo de enterocitos aislados.  en el estudio de la expresi\u00f3n del transportador sglt1 durante el desarrollo se obtuvo una prote\u00edna de 75 kda que disminuye durante el desarrollo. En cambio la expresi\u00f3n del mrna correspondiente, de 3,8 kb no se modificaba en ninguna de las edades estudiadas, demostrando la regulaci\u00f3n mediante un mecanismo de control post-transcripcional. En el transporte basolateral a trav\u00e9s del glut2 se observa una regulaci\u00f3n transcripcional distinta de la observada en el sglt1.  en los estudios de regionalizaci\u00f3n se observ\u00f3 que el sglt1 se expresa en intestino delgado y grueso de pollo. Se encuentra sometido a una distribuci\u00f3n regional, con mayor abundancia en los segmentos proximales que en los distales. esta reducci\u00f3n en el transportador no se acompa\u00f1a de cambios paralelos en la abundancia del rna mensajero, con lo que se deduce que se encuentra regulado mediante un mecanismo, post-transcripcional. La abundancia del mrna del glut2 basolateral presenta una regulaci\u00f3n regional, con valores mayores en duodeno y yeyuno que decrecen hasta llegar a ciego y recto, demostrando una regulaci\u00f3n transcripcional.  la adaptaci\u00f3n a una ingesta con bajo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expressi\u00f3 i regulaci\u00f3 dels transportadors de monosac\u00e1rids intestinals i renals<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expressi\u00f3 i regulaci\u00f3 dels transportadors de monosac\u00e1rids intestinals i renals <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Barfull Font <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joana Mar\u00eda Planas Rossell\u00f3<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Go\u00f1alons sintes <\/li>\n<li>Mar\u00eda del pilar Lostao crespo (vocal)<\/li>\n<li>M\u00aa  anunciacion Ana Inundain larra\u00f1eta (vocal)<\/li>\n<li>josep S\u00e1nchez carralero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Barfull Font En esta tesis se ha estudiado la adaptaci\u00f3n de los transportadores de monosac\u00e1ridos intestinales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,35,675,226],"tags":[64241,13893,19731,32893,44842,33407],"class_list":["post-21259","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-de-la-vida","category-fisiologia-animal","category-zoologia","tag-anna-barfull-font","tag-eduardo-gonalons-sintes","tag-joana-maria-planas-rossello","tag-josep-sanchez-carralero","tag-maria-del-pilar-lostao-crespo","tag-ma-anunciacion-ana-inundain-larraneta"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21259"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21259\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}