{"id":21289,"date":"2018-03-09T09:10:59","date_gmt":"2018-03-09T09:10:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-lesion-de-la-celula-beta-en-el-trasplante-isogenico-de-islotes-de-langerhans\/"},"modified":"2018-03-09T09:10:59","modified_gmt":"2018-03-09T09:10:59","slug":"mecanismos-de-lesion-de-la-celula-beta-en-el-trasplante-isogenico-de-islotes-de-langerhans","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-de-lesion-de-la-celula-beta-en-el-trasplante-isogenico-de-islotes-de-langerhans\/","title":{"rendered":"Mecanismos de lesi\u00f3n de la c\u00e9lula beta en el trasplante isog\u00e9nico de islotes de langerhans"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Biarn\u00e9s Costa <\/strong><\/h2>\n<p>Una de las alternativas de futuro m\u00e1s atractivas para el tratamiento de la diabetes mellitus es el trasplante de islotes pancre\u00e1ticos. La insuficiente cantidad de tejido insular es uno de los principales obstaculos para el trasplante de islotes, adem\u00e1s el problema es m\u00e1s grave debido al elevado n\u00famero de islotes necesarios para realizar un trasplante con \u00e9xito. Se ha sugerido que la presencia de una inflamaci\u00f3n no-especifica en el lugar de implantaci\u00f3n de los islotes podr\u00eda ser una de las causas de la p\u00e9rdida primaria del injerto. El objetivo del estudio fue investigar los procesos que ocurren en los primeros d\u00edas despu\u00e9s del trasplante y espec\u00edficamente los mecanismos de muerte celular en los islotes trasplantados, los procesos inflamatorios que se dan en la zona de implantaci\u00f3n de los islotes y la posible contribuci\u00f3n del estado metab\u00f3lico del receptor. Se trasplantaron animales sing\u00e9nicos diab\u00e9ticos por inyecci\u00f3n con estreptozofocina con una masa insuficiente para restablecer la normoglicemia. Unos animales se mantuvieron hiperglic\u00e9micos durante todo el estudio y otros fueron tratados con insulina y por tanto normalizaron los niveles de glicemica. En los primeros d\u00edas despu\u00e9s del trasplante la masa beta trasplantadas se redujo a la mitad tanto en los animales hiperglic\u00e9micos como normoglic\u00e9micos debido a un aumento de la muerte celular beta por apoptosis y necrosis. Adem\u00e1s se detect\u00f3 la expresi\u00f3n del gen il-1beta y inos en islotes despu\u00e9s del aislamiento y un aumento de la expresi\u00f3n de los genes de il-1beta y inos en islotes despu\u00e9s del aislamiento y un aumento de la expresi\u00f3n de estos genes en injertos en los primeros d\u00edas del trasplante. El aumento de la expresi\u00f3n de los genes de il-1beta y inos se observ\u00f3 tanto en animales diab\u00e9ticos hiperglic\u00e9micos como en animales diab\u00e9licos normoglic\u00e9micos tratados con insulina. Los animales hiperglic\u00e9micos presentaban una expresi\u00f3n menos aumentada de los gen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de lesi\u00f3n de la c\u00e9lula beta en el trasplante isog\u00e9nico de islotes de langerhans<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de lesi\u00f3n de la c\u00e9lula beta en el trasplante isog\u00e9nico de islotes de langerhans <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Biarn\u00e9s Costa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduard Montanya Mias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: isidro Ferrer abizanda <\/li>\n<li>didac Mauricio puente (vocal)<\/li>\n<li>Francisco Mart\u00edn bermudo (vocal)<\/li>\n<li>Marta Vives pi (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Biarn\u00e9s Costa Una de las alternativas de futuro m\u00e1s atractivas para el tratamiento de la diabetes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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