{"id":21311,"date":"2018-03-09T09:11:01","date_gmt":"2018-03-09T09:11:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/presentacion-de-peptidos-por-hla-b27-y-su-posible-papel-en-la-patogenesis-de-las-espondiloartropata%c2%adas\/"},"modified":"2018-03-09T09:11:01","modified_gmt":"2018-03-09T09:11:01","slug":"presentacion-de-peptidos-por-hla-b27-y-su-posible-papel-en-la-patogenesis-de-las-espondiloartropata%c2%adas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/presentacion-de-peptidos-por-hla-b27-y-su-posible-papel-en-la-patogenesis-de-las-espondiloartropata%c2%adas\/","title":{"rendered":"Presentaci\u00f3n de p\u00e9ptidos por hla-b27 y su posible papel en la patog\u00e9nesis de las espondiloartropat\u00edas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Ramos \u00e1lvarez-buylla <\/strong><\/h2>\n<p>El objetivo general de esta tesis fue estudiar el posible papel que tiene la presentaci\u00f3n del p\u00e9ptido por hla-b27 en la patog\u00e9nsis de las espondiloartropat\u00edas. m\u00e1s concretamente, se estudio como se modifica el repertorio de p\u00e9ptidos unidos a hla-b27 en una c\u00e9lula linfoide tras la infecci\u00f3n por una bacteria artritog\u00e9nica, salmonella typhimurium. As\u00ed mismo, se analizaron las diferencias que hay entre los repertorios pept\u00eddicos de dos subtipos de hla-b27 que se asocian diferencialmente a la enfermedad, b*2705 y b*2709. Y se analiz\u00f3 con m\u00e1s detalle uno de los ligandos diferenciales encontrados, que reun\u00edan caracter\u00edsticas potencialmente relevantes en el papel patogen\u00e9tico de hla-b27; uni\u00f3n selectiva a los subtipos de hla-b27 asociados a enfermedad y alta homolog\u00eda con prote\u00ednas de bacterias artritog\u00e9nicas.  finalmente, se identific\u00f3 un nuevo alelo de hla-b39 originario de una poblaci\u00f3n nativa de sudam\u00e9rica que carece de hla-b27. Este nuevo alotipo presenta un cambio que lo aproxima a hla-b27 en sus caracter\u00edsticas de uni\u00f3n de p\u00e9ptidos.  de los resultados obtenidos se concluye:  la infecci\u00f3n por s.Typhimurium produce cambios m\u00ednimos en el repertorio de p\u00e9ptidos unidos a hla-b27 en la c\u00e9lula linfoide hmy2.C1r.  los subtipos b*2705 y b*2709 que se asocian diferencialmente a espondilitis anquilosante comparten el 79% y el 88% respectivamente de su repertorio pept\u00eddico. As\u00ed, los p\u00e9ptidos diferencialmente unidos a b*2705 constituyen el 21% de su repertorio pept\u00eddico y presentan como motivo diferencial un residuo c-terminal b\u00e1sico o tyr. Los p\u00e9ptidos diferencialmente unidos a b*2709 constituyen el 12% de su repertorio pept\u00eddico.  b*2709 une in vivo solamente una peque\u00f1a proporci\u00f3n de p\u00e9ptidos con residuos no apolares en el c-terminal. En esta tesis se han identificado dos p\u00e9ptidos con tyr y arg en posici\u00f3n c-terminal de un total de 41 p\u00e9ptidos secuenciados.  la expresi\u00f3n de cadena pesada libre en la s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Presentaci\u00f3n de p\u00e9ptidos por hla-b27 y su posible papel en la patog\u00e9nesis de las espondiloartropat\u00edas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Presentaci\u00f3n de p\u00e9ptidos por hla-b27 y su posible papel en la patog\u00e9nesis de las espondiloartropat\u00edas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Ramos \u00e1lvarez-buylla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio L\u00f3pez De Castro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: balbino jose Alarcon sanchez <\/li>\n<li>margarita Del val latorre (vocal)<\/li>\n<li>dolores Jaraquemada p\u00e9rez de guzm\u00e1n (vocal)<\/li>\n<li>Juan  pablo Albar ramirez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Ramos \u00e1lvarez-buylla El objetivo general de esta tesis fue estudiar el posible papel que tiene la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[15392,6522,6520,47109,64360,29773],"class_list":["post-21311","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-balbino-jose-alarcon-sanchez","tag-dolores-jaraquemada-perez-de-guzman","tag-jose-antonio-lopez-de-castro","tag-juan-pablo-albar-ramirez","tag-manuel-ramos-alvarez-buylla","tag-margarita-del-val-latorre"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21311"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21311\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}