{"id":21325,"date":"2018-03-09T09:11:02","date_gmt":"2018-03-09T09:11:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-biofarmaceutica-de-sistemas-coloidales-para-el-transporte-de-medicamentos-por-va%c2%ada-ocular\/"},"modified":"2018-03-09T09:11:02","modified_gmt":"2018-03-09T09:11:02","slug":"evaluacion-biofarmaceutica-de-sistemas-coloidales-para-el-transporte-de-medicamentos-por-va%c2%ada-ocular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/evaluacion-biofarmaceutica-de-sistemas-coloidales-para-el-transporte-de-medicamentos-por-va%c2%ada-ocular\/","title":{"rendered":"Evaluaci\u00f3n biofarmac\u00e9utica de sistemas coloidales para el transporte de medicamentos por v\u00edaocular"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Machado De Campos Angela <\/strong><\/h2>\n<p>El objetivo fundamental del presente trabajo ha sido el de evaluar el potencial y el mecanismo de acci\u00f3n de nuevos sistemas coloidaeles, tipo nanopart\u00edculas y nanoc\u00e1psulas, como sistemas de liberaci\u00f3n de f\u00e1rmacos en el globol ocular.  adem\u00e1s, se pretendi\u00f3 progresar en el conocimiento de los factores que determinan la biodistribuci\u00f3n del sistema coloidal tras su administraci\u00f3n t\u00f3pica ocular. as\u00ed, haciendo uso de las tecnolog\u00edas adecuadas, se desarrollaron nanopart\u00edculas de quitosano (cs) y nanoc\u00e1psulas de pli-*-caprolactona (pecl) recubiertas de cs y tambi\u00e9n de polietilenglicol (peg).  los estudios de microscop\u00eda confocal y an\u00e1lisis fluorim\u00e9trico pusieron de manifiesto la interacci\u00f3n favorable y la permanencia prolongada de las nanopart\u00edculas de cs en el epitelio corneal y conjuntival, as\u00ed como su internalizaci\u00f3n en dichos epitelios.  estos resultados explican adem\u00e1s los altos niveles de ciclosporina a alcanzados en cornea y conjuntiva tras su asociaci\u00f3n a nanopart\u00edculas de quitosano.  por otro lado, la formaci\u00f3n de una cubierta hidrf\u00edlica (cs o peg) en torno a las nanoc\u00e1psulas de pecl no modific\u00f3 el mecanismo de transporte transcelular, aunque s\u00ed influy\u00f3 apreciablemente en el alcance y cuant\u00eda de dicho transporte.  concretamente, los resultados sugieren que la cubierta de peg facilita el transporte a trav\u00e9s del epitelio corneal, mientras que la cubierta de cs intensifica la interacci\u00f3n del sistema con el epitelio, pero no su transporte, quedando retenidas estas nanoc\u00e1psulas en las capas m\u00e1s superficiales del epitelio corneal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n biofarmac\u00e9utica de sistemas coloidales para el transporte de medicamentos por v\u00edaocular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n biofarmac\u00e9utica de sistemas coloidales para el transporte de medicamentos por v\u00edaocular <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Machado De Campos Angela <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Alonso Fern\u00e1ndez M. Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Vila jato <\/li>\n<li>rocio Herrero vanrell (vocal)<\/li>\n<li>Miguel Fern\u00e1ndez refojo (vocal)<\/li>\n<li>pilar Calvo salde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Machado De Campos Angela El objetivo fundamental del presente trabajo ha sido el de evaluar el potencial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,3304,977],"tags":[3219,3220,64384,21110,21108,52383],"class_list":["post-21325","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-preparacion-de-farmacos","category-santiago-de-compostela","tag-alonso-fernandez-m-jose","tag-jose-luis-vila-jato","tag-machado-de-campos-angela","tag-miguel-fernandez-refojo","tag-pilar-calvo-salde","tag-rocio-herrero-vanrell"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21325"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21325\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}