{"id":21337,"date":"2018-03-09T09:11:03","date_gmt":"2018-03-09T09:11:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-radicales-libres-de-oxa%c2%adgeno-y-de-la-mitocondria-en-la-apoptosis-inducida-por-el-tgf-beta-en-hapatocitos\/"},"modified":"2018-03-09T09:11:03","modified_gmt":"2018-03-09T09:11:03","slug":"papel-de-los-radicales-libres-de-oxa%c2%adgeno-y-de-la-mitocondria-en-la-apoptosis-inducida-por-el-tgf-beta-en-hapatocitos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-radicales-libres-de-oxa%c2%adgeno-y-de-la-mitocondria-en-la-apoptosis-inducida-por-el-tgf-beta-en-hapatocitos\/","title":{"rendered":"Papel de los radicales libres de ox\u00edgeno y de la mitocondria en la apoptosis inducida por el tgf-beta en hapatocitos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Blanca Herrera Gonz\u00e1lez <\/strong><\/h2>\n<p>El tgf-beta es una prote\u00edna multifuncional que ha sido implicada en el control de diferentes procesos celulares como proliferaci\u00f3n, diferenciaci\u00f3n y apoptosis.  en este trabajo se han estudiado los mecanismos por los que el tgf-beta induce apoptosis en hepatocitos fetales en cultivo primario. El tgf-beta produce muerte en este modelo celular por un mecanismo dependiente de la producci\u00f3n de radicales libres de ox\u00edgeno (ros) y caracterizado por la participaci\u00f3n de la mitocondria.  los ros son responsables de la ca\u00edda en el potencial de membrana mitocondrial, de la salida de citocromo c de este org\u00e1nulo al citosol, de la activaci\u00f3n de caspasas (ciste\u00edn-proteasas) y la ca\u00edda en los niveles de bcl-xl (una prote\u00edan antiapopt\u00f3tica de la familia bcl-2). Las caspasas forman parte de un mecanismo de amplificaci\u00f3n del proceso de muerte, ya que su activaci\u00f3n provoca la ca\u00edda del potencial de membrana mitocondrila, la liberaci\u00f3n tard\u00eda y masiva del citocromo c y la proteolisis de bcl-xl, bid y ciap-1.  tanto jnk como p38mapk son activadas por el tgf-beta. Sin embargo, la activaci\u00f3n de jnk no est\u00e1 relacionada ni con el estr\u00e9s oxidativo ni con la apoptosis inducidas por este factor. Los ros son responsables de la activaci\u00f3n de p38mapk, pero \u00e9sta no est\u00e1 implicada en el mecanismo de muerte disparado por el tgf-beta.  as\u00ed mismo, se han estudiado dos modelos de rsistencia a la apoptosis inducida por el tgf-beta. Por un lado, hemos comprobado que los hepatocitos regenerantes en cultivo primario presentan altos niveles de prote\u00ednas antiapopt\u00f3ticas bcl-xl, ciap-1 y ciap-2. Por otro lado, el egf bloquea el estr\u00e9s oxidativo inducido por el tgf-beta y es capaz, por un mecanismo dependiente de pi 3-k, de impedir los eventos mitocondriales, la ca\u00edda en los niveles de bcl-xl, la activaci\u00f3n de caspasas y la muerte inducidas por el tgf-beta en hepatocitos fetales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los radicales libres de ox\u00edgeno y de la mitocondria en la apoptosis inducida por el tgf-beta en hapatocitos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los radicales libres de ox\u00edgeno y de la mitocondria en la apoptosis inducida por el tgf-beta en hapatocitos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Blanca Herrera Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Isabel Fabregat Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel roman Benito de las heras <\/li>\n<li>Mar\u00eda  Jos\u00e9 G\u00f3mez-lech\u00f3n moliner (vocal)<\/li>\n<li>carmelo Bernabeu quirante (vocal)<\/li>\n<li>\u00e1ngela Mar\u00eda Mart\u00ednez valverde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Blanca Herrera Gonz\u00e1lez El tgf-beta es una prote\u00edna multifuncional que ha sido implicada en el control de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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