{"id":21353,"date":"2018-03-09T09:11:04","date_gmt":"2018-03-09T09:11:04","guid":{"rendered":""},"modified":"2018-03-09T09:11:04","modified_gmt":"2018-03-09T09:11:04","slug":"desarrollo-de-una-metodologa%c2%ada-general-para-la-sa%c2%adntesis-de-productos-naturales-que-ademas-de-su-actividad-biologica-presentan-una-estereoqua%c2%admica-inusual-en-la-naturaleza-trans-sin-t","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-una-metodologa%c2%ada-general-para-la-sa%c2%adntesis-de-productos-naturales-que-ademas-de-su-actividad-biologica-presentan-una-estereoqua%c2%admica-inusual-en-la-naturaleza-trans-sin-t\/","title":{"rendered":"Desarrollo de una metodolog\u00eda general para la s\u00edntesis de productos naturales, que adem\u00e1s de su actividad biol\u00f3gica presentan una estereoqu\u00edmica inusual en la naturaleza (trans-sin-trans o trans-anti-cis)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Khalid Abbassi <\/strong><\/h2>\n<p>Los terpenos representan una amplia familia de productos abundantes en la naturaleza. La mayor\u00eda de ellos se consideran derivados del esqueleto perhidrofenantreno con una esterequ\u00edmica trans-anti-trans entorno a los anillos abc. No obstante, han sido descritos otros sustratos polic\u00edclicos, que adem\u00e1s de su actividad biol\u00f3gica, presentan una estereoqu\u00edmica inusual en la naturaleza trans-sin-trans o trans-anti-cis entorno a los anillos abc.  en general, en el presente trabajo se ha desarrollado una estrategia general encaminada a la elaboraci\u00f3n de estos sistemas a partir de productos de partida quirales sencillos que se incorporan en el n\u00facleo final. En particular, se realiz\u00f3 la s\u00edntesis de un precursos tric\u00edclico, el compuesto (a), que adem\u00e1s de la estereoqu\u00edmica trans-anti-cis en torno a los anillos abc, presenta una funcionalizaci\u00f3n optima para la elaboraci\u00f3n de los productos naturales descritos en la bibliograf\u00eda, coscinafurano (xlii), coscinalactona (xli) y la suvanina (xliii) que ha sido descrita como precursor biosint\u00e9tico de los escalaranos anteriormente mencionados, y que presentan la misma fusi\u00f3n de anillos abc. Del estudio desarrollado para evaluar las dos estrategias seguidas para la preparaci\u00f3n de sesterterpenos tric\u00edclicos con las estereoqu\u00edmicas poco frecuentes de fusi\u00f3n de anillos trans-sin-trans o trans-anti-cis, puede concluirse que:  1,- la utilizaci\u00f3n de la carvona como sint\u00f3n quiral del anillo b en la construcci\u00f3n del sistema triciclo, siguiendo una estrategia del tipo b-ab-abc y utilizando una reacci\u00f3n de diels-alder intermolecular como etapa clave, posibilita un r\u00e1pido y eficaz acceso al mismo, pudi\u00e9ndose llevar a cabo la preparaci\u00f3n de diversos sistemas tric\u00edclicos que tienen el metilo angular en c-8 con la orientaci\u00f3n adecuada y caracter\u00edstica de los sistemas naturales que poseen este tipo de estereoqu\u00edmica. No obstante, en el presente trabajo no ha sido posible establecer la ester<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de una metodolog\u00eda general para la s\u00edntesis de productos naturales, que adem\u00e1s de su actividad biol\u00f3gica presentan una estereoqu\u00edmica inusual en la naturaleza (trans-sin-trans o trans-anti-cis)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de una metodolog\u00eda general para la s\u00edntesis de productos naturales, que adem\u00e1s de su actividad biol\u00f3gica presentan una estereoqu\u00edmica inusual en la naturaleza (trans-sin-trans o trans-anti-cis) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Khalid Abbassi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Abad Somovilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Primo millo <\/li>\n<li>santos Fustero lardi\u00e9s (vocal)<\/li>\n<li>asunci\u00f3n Barbero (vocal)<\/li>\n<li>M\u00aa Luisa Izquierdo ceinos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Khalid Abbassi Los terpenos representan una amplia familia de productos abundantes en la naturaleza. La mayor\u00eda de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[47343,64451,6779,64450,64452,18907],"class_list":["post-21353","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-abad-somovilla","tag-asuncion-barbero","tag-jaime-primo-millo","tag-khalid-abbassi","tag-ma-luisa-izquierdo-ceinos","tag-santos-fustero-lardies"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21353"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21353\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}