{"id":21354,"date":"2018-03-09T09:11:04","date_gmt":"2018-03-09T09:11:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/eficacia-de-la-terapia-genica-con-adenovirus-dl118-en-un-modelo-experimental-de-melanoma-uveal\/"},"modified":"2018-03-09T09:11:04","modified_gmt":"2018-03-09T09:11:04","slug":"eficacia-de-la-terapia-genica-con-adenovirus-dl118-en-un-modelo-experimental-de-melanoma-uveal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/valladolid\/eficacia-de-la-terapia-genica-con-adenovirus-dl118-en-un-modelo-experimental-de-melanoma-uveal\/","title":{"rendered":"Eficacia de la terapia g\u00e9nica con adenovirus dl118 en un modelo experimental de melanoma uveal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis Ordo\u00f1ez Garcia <\/strong><\/h2>\n<p>Introducci\u00f3n  el melanoma uveal es el tumor intraocular maligno m\u00e1s frecuente en el adulto, siendo su incidencia de aproximadamente 6 nuevos casos anuales por mill\u00f3n de habitantes. Una de las caracter\u00edsticas de la enfermedad que s\u00f3lo presentan el 2,4% de los pacientes en el momento del diagn\u00f3stico es la aparici\u00f3n de met\u00e1stasis principalmente en el h\u00edgado, para las que no existe tratamiento eficaz, situ\u00e1ndose  la mortalidad de los pacientes alrededor del 50% a los 10 a\u00f1os del diagn\u00f3stico. Para el estudio de la enfermedad se han desarrollado varios modelos experimentales, de ellos el realizado en conejos albinos inmunosuprimidos con ciclosporina a (csa) mediante el implante de l\u00edneas celulares de melanoma uveal humano es uno de los que mejor refleja el comportamiento de la enfermedad humana. Los tratamiento conservadores que actualmente se aplican frente al tumor primario han permitido el control local de la enfermedad entre un 80-90% de los pacientes pero no se ha conseguido mejorar la supervivencia de los pacientes.  la terapia g\u00e9nica es desde hace m\u00e1s de dos d\u00e9cadas una herramienta terap\u00e9utica \u00fatil para los pacientes con diferentes grados de tumores. En la actualidad se est\u00e1nllevando a cabo en pacientes con tumores de cabeza y cuello estudios cl\u00ednicos de terapia g\u00e9nica en fase iii con adenovirus de replicaci\u00f3n selectiva (dl 1520) que tienen delecionado parcialmente el gen e1b y que expresan e1a. Un adenovirus serotipo 5 similar al anterior y que tiene delecionado la regi\u00f3n e1b completa (dl118) ha demostrado en estudios in vitro e in vivo disminuir el crecimiento tumoral e impedir la formaci\u00f3n de met\u00e1stasis.  el objetivo de este estudio ha sido determinar el efecto citop\u00e1tico de los adenovirus dl118 sobre diferentes l\u00edneas celulares de melanoma uveal humano y adem\u00e1s estudiar el efecto antitumoral de la aplicaci\u00f3n de estos adenovirus en un modelo e melanoma uveal en conejo albino inmunosuprimido con csa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia de la terapia g\u00e9nica con adenovirus dl118 en un modelo experimental de melanoma uveal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia de la terapia g\u00e9nica con adenovirus dl118 en un modelo experimental de melanoma uveal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis Ordo\u00f1ez Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Saornil \u00e1lvarez M. Antonia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Carlos Pastor jimeno <\/li>\n<li>Santiago Ramon y cajal ag\u00ed\u00bceras (vocal)<\/li>\n<li>ru\u00ed Proen\u00ed\u00a7a (vocal)<\/li>\n<li>Jos\u00e9 Garc\u00eda arum\u00ed (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis Ordo\u00f1ez Garcia Introducci\u00f3n el melanoma uveal es el tumor intraocular maligno m\u00e1s frecuente en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[12451],"tags":[12508,53494,64453,64454,36351,62684],"class_list":["post-21354","post","type-post","status-publish","format-standard","hentry","category-valladolid","tag-jose-carlos-pastor-jimeno","tag-jose-garcia-arumi","tag-jose-luis-ordonez-garcia","tag-rui-proenia","tag-santiago-ramon-y-cajal-agieras","tag-saornil-alvarez-m-antonia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21354"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21354\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}