{"id":21366,"date":"2018-03-09T09:11:05","date_gmt":"2018-03-09T09:11:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-las-propiedades-hemostaticas-del-endotelio-por-el-oxido-na%c2%adtrico-en-presencia-de-endotoxina\/"},"modified":"2018-03-09T09:11:05","modified_gmt":"2018-03-09T09:11:05","slug":"modulacion-de-las-propiedades-hemostaticas-del-endotelio-por-el-oxido-na%c2%adtrico-en-presencia-de-endotoxina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/modulacion-de-las-propiedades-hemostaticas-del-endotelio-por-el-oxido-na%c2%adtrico-en-presencia-de-endotoxina\/","title":{"rendered":"Modulaci\u00f3n de las propiedades hemost\u00e1ticas del endotelio por el \u00f3xido n\u00edtrico en presencia de endotoxina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel P\u00e9rez Ruiz <\/strong><\/h2>\n<p>La endotoxina meida la mayor parte de mecanismos que se desencadenan en respuesta a la infecci\u00f3n por bacterias gram negativas y que originan los s\u00edntomas de sepsis. Entre otras acciones, la endotoxina altera las propiedades del endotelio, que pasa de ser una superficie tromborresistente a ser una superficie protromb\u00f3tica, especialmente debido al incremento en la expresi\u00f3n de factor tisular, que activa la coagulaci\u00f3n, y del inhibidor del activador del plasmin\u00f3geno-1 (pai-1), que inhibe la fibrinolisis. Por otro lado, el \u00f3xido n\u00edtrico (no) es una mol\u00e9cula cuyos niveles se incrementan notablemente en la sepsis debido a la inducci\u00f3n por endotoxina de la enzima \u00f3xido n\u00edtrico sintetasa inducible (inos). Parece que este aumento del no podr\u00eda ser responsable de una serie de efectos indeseables en la sepsis, especialmente de una potente vasodilataci\u00f3n que contribuir\u00eda a la aparici\u00f3n del cuadro de shock. sin embargo, existen indicios de que el no podr\u00eda jugar un papel antitromb\u00f3tico, ya que en modelos animales de endotoxemia se ha descrito un aumento de los dep\u00f3sitos de fibrina en varios \u00f3rganos a consecuencia de la inhibici\u00f3n de la inos. El objetivo de este proyecto ha sido estudiar el efecto de la modulaci\u00f3n de los niveles de no sobre las propiedades hemost\u00e1ticas del endotelio en presencia de endotoxina: el estudio se ha centrado en la expresi\u00f3n de factor tisular y pai-1, aunque para obtener una visi\u00f3n m\u00e1s global de la respuesta hemost\u00e1tica del endotelio tambi\u00e9n se han estudiado el inhibidor de la v\u00eda extr\u00ednseca de la coagulaci\u00f3n (tfpi) y el receptor endotelial de la prote\u00edna c\/prote\u00edna c activada (epcr), ambas tambi\u00e9n de s\u00edntesis endotelial. Como endotelio se emplearon c\u00e9lulas de vena de cord\u00f3n umbilical humano, a las que se incub\u00f3 con endotoxina durante dos, seis o 24 horas, sola o en presencia de un inhibidor de las sintetasas de no (l-name) o de un dador ex\u00f3geno de no (snap). La endotoxina indujo un notabl<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de las propiedades hemost\u00e1ticas del endotelio por el \u00f3xido n\u00edtrico en presencia de endotoxina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de las propiedades hemost\u00e1ticas del endotelio por el \u00f3xido n\u00edtrico en presencia de endotoxina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel P\u00e9rez Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Montes D\u00edaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li>Francisco Velasco gimena (vocal)<\/li>\n<li>amparo Estell\u00e9s cort\u00e9s (vocal)<\/li>\n<li>Javier Fern\u00e1ndez d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel P\u00e9rez Ruiz La endotoxina meida la mayor parte de mecanismos que se desencadenan en respuesta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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