{"id":21412,"date":"2018-03-09T09:11:11","date_gmt":"2018-03-09T09:11:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-neuroprotector-de-triflusal-en-un-modelo-experimental-de-anoxia-reoxigenacion\/"},"modified":"2018-03-09T09:11:11","modified_gmt":"2018-03-09T09:11:11","slug":"efecto-neuroprotector-de-triflusal-en-un-modelo-experimental-de-anoxia-reoxigenacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/efecto-neuroprotector-de-triflusal-en-un-modelo-experimental-de-anoxia-reoxigenacion\/","title":{"rendered":"Efecto neuroprotector de triflusal en un modelo experimental de anoxia-reoxigenaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ure\u00f1a Garnica M. Isabel <\/strong><\/h2>\n<p>Acido acetilsalic\u00edlico es el f\u00e1rmaco m\u00e1s utilizado en prevenci\u00f3n de los accidentes cerebrovasculares isqu\u00e9micos en nuestro medio. El mecanismo por el que se produce este efecto se debe a la inhibici\u00f3n de la agregaci\u00f3n plaquetaria y por lo tanto, de la formaci\u00f3n de un trombo en el sector arterial. no obstante, recientemente se ha demostrado que tambi\u00e9n ejerce un efecto neuroprotector director. En nuestro medio, triflusal es un derviado salic\u00edlico muy utilizado en estos procesos, de ah\u00ed que el objetivo del presente trabajo es valorar el posible efecto directo de triflusal en un modelo experimental de anoxia-reoxigenaci\u00f3n.  el estudio se llev\u00f3 a cabo en ratas wistar machos. En los experimentos in vitro, se sacrificaron a los animales y se incub\u00f3 el f\u00e1rmaco en cortes cerebrales a los que se someti\u00f3 a un periodo de anoxia seguido de otro de reoxigenaci\u00f3n. En los experimentos ex vivo, se administr\u00f3 triflusal, \u00e1cido acetilsalic\u00edlico y sus metabolitos respectivos (htb y \u00e1cido salic\u00edlico) por v\u00eda oral durante 7 d\u00edas, transcurridos los cuales se procedi\u00f3 al sacrificio de los animales y al modelo de anoxia-reoxigenaci\u00f3n. En cada caso se determinaron par\u00e1metros de estr\u00e9s oxidativo (peroxidaci\u00f3n lip\u00eddica, sistema de glutati\u00f3n), concentraci\u00f3n de prostaglandinas cerebrales y v\u00eda del \u00f3xido n\u00edtrico (no) (producci\u00f3n de nitritos y actividad enzim\u00e1tica no sintasa constitutiva -cnos- e inducible -inos-), as\u00ed como actividad ldh como \u00edndice de muerte celular.  el modelo experimental utilizado produjo un claro incremento de estr\u00e9s oxidativo (aumento de peroxidaci\u00f3n lip\u00eddica y disminuci\u00f3n de los niveles de glutation), un ac\u00famulo de prostaglandinas y una hiperactividad de la actividad inos con el consiguiente incremento global en la producci\u00f3n de no.  la incubaci\u00f3n de los f\u00e1rmacos de estudio produjo una reducci\u00f3n del estr\u00e9s oxidativo, una reducci\u00f3n del ac\u00famulo de prostaglandinas y una disminuci\u00f3n de la produc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto neuroprotector de triflusal en un modelo experimental de anoxia-reoxigenaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto neuroprotector de triflusal en un modelo experimental de anoxia-reoxigenaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ure\u00f1a Garnica M. Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Jan\u00e9 carrenca <\/li>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez correa (vocal)<\/li>\n<li>Jes\u00fas Honorato perez (vocal)<\/li>\n<li>florentina Diaz soto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ure\u00f1a Garnica M. Isabel Acido acetilsalic\u00edlico es el f\u00e1rmaco m\u00e1s utilizado en prevenci\u00f3n de los accidentes cerebrovasculares [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[7834],"tags":[64587,51,17752,24766,7864,64586],"class_list":["post-21412","post","type-post","status-publish","format-standard","hentry","category-malaga","tag-florentina-diaz-soto","tag-francesc-jane-carrenca","tag-jesus-honorato-perez","tag-jose-antonio-gonzalez-correa","tag-jose-pedro-de-la-cruz-cortes","tag-urena-garnica-m-isabel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21412","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21412"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21412\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}