{"id":21415,"date":"2018-03-09T09:11:11","date_gmt":"2018-03-09T09:11:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dimorfismo-en-yarrowia-lipolytica-y-candida-albicans-aislamiento-del-gen-sin3-un-factor-de-regulacion-transcripcional\/"},"modified":"2018-03-09T09:11:11","modified_gmt":"2018-03-09T09:11:11","slug":"dimorfismo-en-yarrowia-lipolytica-y-candida-albicans-aislamiento-del-gen-sin3-un-factor-de-regulacion-transcripcional","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/dimorfismo-en-yarrowia-lipolytica-y-candida-albicans-aislamiento-del-gen-sin3-un-factor-de-regulacion-transcripcional\/","title":{"rendered":"Dimorfismo en yarrowia lipolytica y candida albicans. aislamiento del gen sin3, un factor de regulaci\u00f3n transcripcional"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Monterola Quiaro Freida Carmen <\/strong><\/h2>\n<p>El dimorfismo es la capacidad que presentan algunos hongos para crecer de dos manera diferentes, en forma circular o esf\u00e9rica (levaduras) y en forma filamentosa (hifas y\/o pseudohifas). La transici\u00f3n dim\u00f3rfica depende de dos factores:  1,- de la naturaleza, n\u00famero e intensidad de las se\u00f1ales ambientales.  2,- de la actividad de v\u00edas de se\u00f1alizaci\u00f3n que convergen en factores de transcripci\u00f3n diferentes o id\u00e9nticos que controlan la expresi\u00f3n de genes espec\u00edficos de morfolog\u00eda.  el gen sin3 de saccharomyces cerevisiae codifica una prote\u00edna que est\u00e1 presente en un gran complejo multiprote\u00edco que incluye a la descacetilasa de histona rpd3p. La prote\u00edna sin3p funciona como un represor transcripcional de numerosos genes que intervienen en una amplia variedad de procesos biol\u00f3gicos, alterando el estado de acetilaci\u00f3n de la cromatina.  nosotros aislamos y delecionamos el gen sin3 de candida albicans y yarrowia lipolytica con el objeto de estudiar si este gen est\u00e1 implicado en el proceso dim\u00f3rfico. El gen sin3 en estas dos levaduras, presenta cuatro motivos alfa h\u00e9lices anfip\u00e1ticos los cuales est\u00e1n muy conservados en la evoluci\u00f3n y se ha sugerido que media la interacci\u00f3n entre prote\u00ednas.  nosotros observamos que los mutantes sin3 en estas levaduras presentan un bloqueo en la formaci\u00f3n de hifas tanto en medio s\u00f3lido como en medio l\u00edquido, formando pseudohifas.  el mutante sin3\/sin3 de c.Albicans origina una alteraci\u00f3n de la expresi\u00f3n de los genes efg1, cph1 y tec1. Estos codifican factores transcripcionales que regulan el proceso dim\u00f3rfico en este hongo pat\u00f3geno.  adem\u00e1s, estos mutantes presentan defectos en la pared celular y alteraci\u00f3n en la expresi\u00f3n de genes de la fosfatasa \u00e1cida. Nuestros datos demuestran que la ausencia del gen sin3 produce un efecto pleiotr\u00f3pico en la expresi\u00f3n g\u00e9nica, que pudiera ser debido a alteraciones en la conformaci\u00f3n de la cromatina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dimorfismo en yarrowia lipolytica y candida albicans. aislamiento del gen sin3, un factor de regulaci\u00f3n transcripcional<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dimorfismo en yarrowia lipolytica y candida albicans. aislamiento del gen sin3, un factor de regulaci\u00f3n transcripcional <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Monterola Quiaro Freida Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/01\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Dom\u00ednguez Olavarri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 pedro Martinez garcia <\/li>\n<li>estrella Mart\u00edn manzuelos (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gil santos (vocal)<\/li>\n<li>lu\u00eds Fern\u00e1ndez lagos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monterola Quiaro Freida Carmen El dimorfismo es la capacidad que presentan algunos hongos para crecer de dos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[9537,64594,4501,1259,64595,64593],"class_list":["post-21415","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-angel-dominguez-olavarri","tag-estrella-martin-manzuelos","tag-jose-antonio-gil-santos","tag-jose-pedro-Martinez-garcia","tag-luis-fernandez-lagos","tag-monterola-quiaro-freida-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21415"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21415\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}