{"id":21491,"date":"2003-03-02T00:00:00","date_gmt":"2003-03-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diferentes-estrategias-de-estabilizacion-de-penicilina-g-acilasa-frente-a-disolventes-organicos-aplicaciones-en-sa%c2%adntesis\/"},"modified":"2003-03-02T00:00:00","modified_gmt":"2003-03-02T00:00:00","slug":"diferentes-estrategias-de-estabilizacion-de-penicilina-g-acilasa-frente-a-disolventes-organicos-aplicaciones-en-sa%c2%adntesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diferentes-estrategias-de-estabilizacion-de-penicilina-g-acilasa-frente-a-disolventes-organicos-aplicaciones-en-sa%c2%adntesis\/","title":{"rendered":"Diferentes estrategias de estabilizaci\u00f3n de penicilina g acilasa frente a disolventes org\u00e1nicos: aplicaciones en s\u00edntesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Abian Franco Olga M. <\/strong><\/h2>\n<p>En esta tesis doctoral hemos logrado un avance muy significativo tanto en su objetivo principal, \u00abdise\u00f1os de nuevos procesos de s\u00edntesis con derivados de penicilina g acilasa altamente activados frente a disolventes org\u00e1nicos\u00bb, como en los tres sub-objetivos planteados:  a,- dise\u00f1o de una nueva estrategia de hiper-estabilizaci\u00f3n de enzimas frente a disolventes org\u00e1nicos mediante una combinaci\u00f3n de inmovilizaci\u00f3n covalente multipuntual sobre soportes pre-existentes y de una hiper-hidrolizaci\u00f3n adicional de todas y cada una de las mol\u00e9culas de enzimas inmovilizadas que quedan rodeadas de una nano-capa polim\u00e9rica de polietilenimina y dextrano aldeh\u00eddo y dextrano sulfato.  b,- dise\u00f1o de nuevos y mejores procesos de s\u00edntesis aprovechando la posibilidad de utilizar la enzima pga en presencia de altas concentraciones de disolventes org\u00e1nicos: mejoras de rendimientos y enantioselectividad.  c,- dise\u00f1o de nuevas estrategias de estabilizaci\u00f3n de pga por mejora de la inmovilizaci\u00f3n covalente multipuntal mediante mutag\u00e9nesis dirigida de la superficie de la enzima aumentando la densidad superficial de residuos lisina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Diferentes estrategias de estabilizaci\u00f3n de penicilina g acilasa frente a disolventes org\u00e1nicos: aplicaciones en s\u00edntesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Diferentes estrategias de estabilizaci\u00f3n de penicilina g acilasa frente a disolventes org\u00e1nicos: aplicaciones en s\u00edntesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Abian Franco Olga M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Manuel Guis\u00e1n Seijas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos G\u00f3mez moreno <\/li>\n<li>Jos\u00e9 Luis Garcia lopez (vocal)<\/li>\n<li>Javier Sancho sanz (vocal)<\/li>\n<li>Jos\u00e9 Berenguer Carlos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Abian Franco Olga M. En esta tesis doctoral hemos logrado un avance muy significativo tanto en su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[64773,35678,29014,6063,8509,24291],"class_list":["post-21491","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-abian-franco-olga-m","tag-carlos-gomez-moreno","tag-javier-sancho-sanz","tag-jose-berenguer-carlos","tag-jose-luis-garcia-lopez","tag-jose-manuel-guisan-seijas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21491"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21491\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}