{"id":21542,"date":"2003-06-02T00:00:00","date_gmt":"2003-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-farmacocinetico-farmacodinamico-del-5-fluorouracilo-a-altas-dosis-en-regimen-de-poliquimioterapia-en-tumores-gastrointestinales\/"},"modified":"2003-06-02T00:00:00","modified_gmt":"2003-06-02T00:00:00","slug":"analisis-farmacocinetico-farmacodinamico-del-5-fluorouracilo-a-altas-dosis-en-regimen-de-poliquimioterapia-en-tumores-gastrointestinales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/analisis-farmacocinetico-farmacodinamico-del-5-fluorouracilo-a-altas-dosis-en-regimen-de-poliquimioterapia-en-tumores-gastrointestinales\/","title":{"rendered":"An\u00e1lisis farmacocin\u00e9tico-farmacodin\u00e1mico del 5-fluorouracilo a altas dosis en r\u00e9gimen de poliquimioterapia en tumores gastrointestinales"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garz\u00f3n Hern\u00e1ndez Carlos Alejandro <\/strong><\/h2>\n<p>Objetivo  evaluar la factibilidad de modular la toxicidad hematol\u00f3gica del 5-fu a altas dosis en r\u00e9gimen de poliquimioterapia por m\u00e9todos farmacocin\u00e9ticos (pk).  pacientes y m\u00e9todos  31 pacientes (17 hombres\/14 mujeres) con carcinoma colorrectal avanzado fueron incluidos desde mayo de 1999 a mayo de 2001 en un estudio prospectivo para determinar los par\u00e1metros pk del 5-fu. La mediana de edad fue de 60 a\u00f1os (rango 51-66). El r\u00e9gimen de quimioterapia fue: 5-fu (2,6 g\/m2) en infusi\u00f3n de 24-h, leucovorin (500 mg\/m2) en infusi\u00f3n de 24-h, oxaliplatino\/raltitrexed (120 mg\/m2; 3mg\/m2), irinotecan (250 mg\/m2).  el an\u00e1lisis farmacocin\u00e9tico del 5-fu fue realizado en 40 ciclos. La toxicidad hematol\u00f3gica fue evaluada de acuerdo a los criterios del nci a los 8 d\u00edas de iniciado el tratamiento (nadir). Un an\u00e1lisis de regresi\u00f3n log\u00edstica univariante y multivariante fue realizado. La variable dependiente fue la neutropenia: no (grados 0-1) o si (grade&gt;2).  las variables independientes fueron: \u00e1rea bajo la curva concentraci\u00f3n-tiempo del 5-fu (auc5-fu), edad, sexo, dosis de irinotecan y raltitrexed (si\/no).  resultados  la media de los par\u00e1metros pk del 5-fu fueron: aclaramiento 3,3 ml\/min (0.75); volumen de distribuci\u00f3n 0,45 (0.11) l\/kg; auc5-fu 22,08 mg h\/l (5.24).  la toxicidad hematol\u00f3gica observada fue: neutropenia grado 1 en 17 ciclos, grado 2 en 7 ciclos, y grado 3 en 4 ciclos. No fue observada neutropenia grado 4.  un valor de auc5-fu de 25,15 mg h\/l fue encontrado como punto de corte por un an\u00e1lisis con curva roc (sensibilidad 70%, especificidad 80%) para predecir neutropenia por encima del grado 1. El \u00e1rea bajo la curva de la curva roc fue 0,76 (p=0,02).  conclusi\u00f3n  la estimaci\u00f3n de la exposici\u00f3n sist\u00e9mica del 5-fu (auc) es efectiva para predecir neutropenia en paciente con ccr avanzado tratados con 5-fu a altas dosis en r\u00e9gimen de poliquimioterapia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis farmacocin\u00e9tico-farmacodin\u00e1mico del 5-fluorouracilo a altas dosis en r\u00e9gimen de poliquimioterapia en tumores gastrointestinales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis farmacocin\u00e9tico-farmacodin\u00e1mico del 5-fluorouracilo a altas dosis en r\u00e9gimen de poliquimioterapia en tumores gastrointestinales <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garz\u00f3n Hern\u00e1ndez Carlos Alejandro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Garcia Foncillas Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  ignacio Arenas mirave <\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<li>enrique Aranda aguilar (vocal)<\/li>\n<li> Illarramendi ma\u00f1as Jos\u00e9 Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garz\u00f3n Hern\u00e1ndez Carlos Alejandro Objetivo evaluar la factibilidad de modular la toxicidad hematol\u00f3gica del 5-fu a altas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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