{"id":2158,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/alopurinol-en-la-isquemia-y-reperfusion-hepatica-experimental\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"alopurinol-en-la-isquemia-y-reperfusion-hepatica-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alopurinol-en-la-isquemia-y-reperfusion-hepatica-experimental\/","title":{"rendered":"Alopurinol en la isquemia y reperfusion hepatica experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Martinez Revuelta <\/strong><\/h2>\n<p>Introduccion y objetivos. Tiene gran interes actual el estudio de la isquemia y reperfusion de organos debido sobre todo a la expansion de la cirugia de recambio de organos. El objeto de este estudio es conocer las alteraciones de la isquemia seguida de reperfusion en un modelo experimental hepatico y ensayar el efecto del alopurinol.  hipotesis, material y metodos. Se trata de estudiar el efecto de la isquemia, de la reperfusion y el eventual beneficio del alopurinol como inhibidor de la xantin-oxidasa. Se emplean 42 ratas wistar y se hace un protocolo de 7 grupos (normal, isquemia de 15 min, isquemia de 30 min, reperfusion tras la isquemia corta y larga y alopurinol aplicado tras los dos grupos de reperfusion. Se evaluan parametros funcionales, peroxidacion (malondialdehido) y alteraciones histologicas y ultraestructurales.  resultados. Se observa que la reperfusion a\u00f1ade da\u00f1o adicional y que el alopurinol reduce este da\u00f1o solamente si la isquemia fue de 30 min. Asimismo se observa que los parametros mas fieles son la determinacion de malondialdehido y la cuantificacion de las alteraciones ultraestructurales.  conclusion. El alopurinol tiene un discreto beneficio sobre la isquemia-reperfusion hepatica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alopurinol en la isquemia y reperfusion hepatica experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alopurinol en la isquemia y reperfusion hepatica experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Martinez Revuelta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Martinez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Sebastian Lopez Arranz <\/li>\n<li>Alberto Gomez Alonso (vocal)<\/li>\n<li>Jos\u00e9 Luis Balibrea  Cantero (vocal)<\/li>\n<li>Luis Rodrigo Saez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Martinez Revuelta Introduccion y objetivos. Tiene gran interes actual el estudio de la isquemia y reperfusion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,387,10,8846],"tags":[9244,8848,4963,7475,9097,9243],"class_list":["post-2158","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-abdominal","category-cirugia-de-trasplantes","category-oviedo","tag-alberto-gomez-alonso","tag-enrique-Martinez-rodriguez","tag-jose-luis-balibrea-cantero","tag-juan-sebastian-lopez-arranz","tag-luis-rodrigo-saez","tag-maria-Martinez-revuelta"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=2158"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2158\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=2158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=2158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=2158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}