{"id":21599,"date":"2003-12-02T00:00:00","date_gmt":"2003-12-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-leucocito-endotelio-y-mobilizacion-de-celulas-neoplasicas-circulantes-en-el-cancer-colorrectal\/"},"modified":"2003-12-02T00:00:00","modified_gmt":"2003-12-02T00:00:00","slug":"interaccion-leucocito-endotelio-y-mobilizacion-de-celulas-neoplasicas-circulantes-en-el-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/interaccion-leucocito-endotelio-y-mobilizacion-de-celulas-neoplasicas-circulantes-en-el-cancer-colorrectal\/","title":{"rendered":"Interacci\u00f3n leucocito-endotelio y mobilizaci\u00f3n de c\u00e9lulas neopl\u00e1sicas circulantes en el c\u00e1ncer colorrectal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier Bessa Caserras <\/strong><\/h2>\n<p>El proceso de diseminaci\u00f3n metast\u00e1sico en el c\u00e1ncer colorectal es un proceso complejo y multifactorial. La presente tesis ha pretendido profundizar en dos aspectos: los mecanismos de defensa inmunol\u00f3gico a trav\u00e9s de la caracterizaci\u00f3n de los fen\u00f3menos de interacci\u00f3n leucocitaria, y el proceso de mobilizaci\u00f3n tumoral a trav\u00e9s de la detecci\u00f3n y pron\u00f3stico de las c\u00e9lulas neopl\u00e1sicas circulantes.  en la presente tesis se ha confirmado que existe una deficiente interacci\u00f3n de los leucocitos circulantes con el endotelio de los vasos tumorales respecto al endotelio no tumoral, tanto de rodamiento en condiciones basales como de adhesi\u00f3n tras la administraci\u00f3n de un est\u00edmulo inflamatorio. Se ha demostrado que la mol\u00e9cula implicada en los fen\u00f3menos de adhesi\u00f3n leucocitaria es icam-1, ya que su inmunobloqueo revierte los fen\u00f3menos de adhesi\u00f3n inducidos por lps. Se ha demostrado a trav\u00e9s de la t\u00e9cnica del doble marcage con anticuerpos que la deficiente interacci\u00f3n leucocito-endotelio a nivel tumoral no puede atribuirse a una menor expresi\u00f3n de las diferentes mol\u00e9culas de adhesi\u00f3n implicadas en dicho fen\u00f3meno. Al intentar evaluar los mecanismos responsables de la deficiente interacci\u00f3n leucocito endotelio se descart\u00f3 la participaci\u00f3n del ant\u00edgeno carcinoembrionario, los productos derivados de la ciclooxigenasa y la sintasa inducible del \u00f3xido n\u00edtrico. No obstante se demostr\u00f3 que la inhibici\u00f3n no selectiva de la sintasa del \u00f3xido n\u00edtrico aumentaba de manera dosis-dependiente el rodamiento leucocitario y la adhesi\u00f3n post-lps a nivel del tejido tumoral. Efecto similar se observo al proceder al inmunobloqueo del factor transformante b1. Por tanto, de los resultados obtenidos, se puede resaltar que tanto el \u00f3xido n\u00edtrico como el factor de crecimiento transformante b1 participan, al menos de manera parcial, en los fen\u00f3menos de escape de los sistemas de inmunovigilancia a nivel tumoral.  la segunda parte de la tes<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacci\u00f3n leucocito-endotelio y mobilizaci\u00f3n de c\u00e9lulas neopl\u00e1sicas circulantes en el c\u00e1ncer colorrectal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacci\u00f3n leucocito-endotelio y mobilizaci\u00f3n de c\u00e9lulas neopl\u00e1sicas circulantes en el c\u00e1ncer colorrectal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier Bessa Caserras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Mar\u00eda Pique Badia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Perez mateo regadera <\/li>\n<li>montserrat Andreu garcia (vocal)<\/li>\n<li>elies Campo guerri (vocal)<\/li>\n<li>pere Gascon vilaplana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier Bessa Caserras El proceso de diseminaci\u00f3n metast\u00e1sico en el c\u00e1ncer colorectal es un proceso complejo y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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