{"id":21631,"date":"2018-03-09T09:11:29","date_gmt":"2018-03-09T09:11:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ciclolignanos-citotoxicos-de-podofilotoxina-nuevos-analogos-nitrogenados\/"},"modified":"2018-03-09T09:11:29","modified_gmt":"2018-03-09T09:11:29","slug":"ciclolignanos-citotoxicos-de-podofilotoxina-nuevos-analogos-nitrogenados","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/ciclolignanos-citotoxicos-de-podofilotoxina-nuevos-analogos-nitrogenados\/","title":{"rendered":"Ciclolignanos citot\u00f3xicos de podofilotoxina: nuevos an\u00e1logos nitrogenados"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Antonia G\u00f3mez-zurita Frau <\/strong><\/h2>\n<p>El descubrimiento, d\u00e9cadas atr\u00e1s, de la actividad antitumoral de podofilotoxina convirti\u00f3 a dicha mol\u00e9cula en el objetivo de numerosos estudios y transformaciones encaminadas a preparar nuevos an\u00e1logos que mejorasen sus propiedades terap\u00e9uticas, incrementando su potencia citot\u00f3xica y presentando una mayor selectividad, que se traducir\u00eda en una reducci\u00f3n de los efectos secundarios sobre el organismo.  entre los an\u00e1logos obtenidos en los \u00faltimos a\u00f1os por nuestro grupo investigador destaca el \u00e1cido isoxazopodof\u00edlico, que present\u00f3 una interesante actividad inmunosupresora, a consecuencia de la cual fue seleccionado para su evaluaci\u00f3n in vivo, y el aldeh\u00eddo alfa,beta-insaturado 9-desoxi-9-oxo-alfa-apopicropodofilato de metilo, que ha mostrado una destacable citotoxicidad selectiva para el carcinoma de colon humano ht-29. Ambos se han convertido en los precursores de nuevas familias de an\u00e1logos ciclolign\u00e1nicos.  as\u00ed, se han sintetizado a partir del \u00e1cido isoxaxopodof\u00edlico mol\u00e9culas en las que han sido modificados los anillos a o e del esqueleto de ciclolignano, manteni\u00e9ndose el anillo de isoxazol fusionado.  por otra parte, a partir del aldeh\u00eddo alfa,beta-insaturado, y por condensaci\u00f3n con diferentes tipos de nucle\u00f3filos nitrogenados, se han sintetizado series de derivados am\u00eddicos, im\u00ednicos, tiazolidin\u00f3nicos, imidaz\u00f3licos, benzoxaz\u00f3licos y benzotiaz\u00f3licos.  los compuetos obtenidos se eval\u00faan frente a las l\u00edneas celulares neopl\u00e1sicas p-388, a-549, ht-29 y mel-28 y, en algunos casos, frente a las l\u00edneas h-116, ms-1 y pc-3.  de todos ellos cabe destacar los derivados de tipo im\u00ednico por su selectividad frente al carcinoma ht-29 y por la mejora, en algunos casos, de los valores de citotoxicidad con respecto al aldeh\u00eddo del que proceden.  palabras clave  ciclolignano, inmunosupresi\u00f3n, antineopl\u00e1sicos, selectividad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ciclolignanos citot\u00f3xicos de podofilotoxina: nuevos an\u00e1logos nitrogenados<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ciclolignanos citot\u00f3xicos de podofilotoxina: nuevos an\u00e1logos nitrogenados <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Antonia G\u00f3mez-zurita Frau <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  De Los Angeles Castro Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Grande benito <\/li>\n<li>Carlos Jim\u00e9nez gonz\u00e1lez (vocal)<\/li>\n<li>angel Gutierrez ravelo (vocal)<\/li>\n<li>librada Mar\u00eda Ca\u00f1edo hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Antonia G\u00f3mez-zurita Frau El descubrimiento, d\u00e9cadas atr\u00e1s, de la actividad antitumoral de podofilotoxina convirti\u00f3 a dicha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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