{"id":21645,"date":"2018-03-09T09:11:31","date_gmt":"2018-03-09T09:11:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/eficacia-de-la-perfusion-normotermica-sangua%c2%adnea-en-la-preservacion-hepatica\/"},"modified":"2018-03-09T09:11:31","modified_gmt":"2018-03-09T09:11:31","slug":"eficacia-de-la-perfusion-normotermica-sangua%c2%adnea-en-la-preservacion-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/eficacia-de-la-perfusion-normotermica-sangua%c2%adnea-en-la-preservacion-hepatica\/","title":{"rendered":"Eficacia de la perfusi\u00f3n normot\u00e9rmica sangu\u00ednea en la preservaci\u00f3n hep\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> I\u00f1igo L\u00f3pez Cenarruzabeitia <\/strong><\/h2>\n<p>El \u00e9xito que ha supuesto el trasplante en los \u00faltimo a\u00f1os ha revelado la escasez de \u00f3rganos, necesarios para facilitar la terapia apropiada para esos pacientes que precisan de este tratamiento. En los \u00faltimos a\u00f1os ha surgido un renovado inter\u00e9s en diferentes campos de investigaci\u00f3n, con el objeto de incrementar est\u00e9 n\u00famero de \u00f3rganos, como es el caso de la preservaci\u00f3n de \u00f3rganos. Los m\u00e9todos cl\u00e1sicos de conservaci\u00f3n, que abocan al da\u00f1o por isquemia, han demostrado ser incapaces de mantener la viabilidad de \u00f3rganos procedentes, de lo que se ha denominado, \u00abdonates marginales\u00bb. previos estudios han revelado la perfusi\u00f3n normot\u00e9rmica como un m\u00e9todo de gran eficacia para abastecer de ox\u00edgeno y nutrientes a la c\u00e9lula, evitando el da\u00f1o por isquemia, manteniendo \u00f3rganos viables, durante 72 horas. El objeto de este estudio ha sido investigar si la preservaci\u00f3n del \u00f3rgano aislado, mediante perfusi\u00f3n, continua normot\u00e9rmica, es un m\u00e9todo viable y si ofrece ventajas sobre la preservaci\u00f3n est\u00e1tica hipot\u00e9rmica con soluci\u00f3n de wisconsin. Con el fin de demostrar este extremo, h\u00edgados porcinos preservados mediante perfusi\u00f3n continua normot\u00e9rmica se compararon con otros preservados con soluci\u00f3n de wisconsin, como m\u00e9todo control. Para preservar los h\u00edgados se utiliz\u00f3 un bypass cardiopulmonar pediatr\u00edco, proveyendo de sangre alog\u00e9nica normot\u00e9rmica al h\u00edgado aislado v\u00eda portal y arterial, siendo recirculada. tras el per\u00edodo de preservaci\u00f3n los h\u00edgados de ambos grupos se rerperfundiero, utilizando el ciercuito como si del receptor se tratara, y se estudi\u00f3 el comportamiento de estos \u00f3rganos durante la reperfusi\u00f3n. Como resultado, ha quedado claramente demostrada la superioridad de la preservaci\u00f3n normat\u00e9rmica, como reflejan los par\u00e1metros estudiados de da\u00f1o hepatocelular, metab\u00f3licos, sint\u00e9ticos, secretores, f\u00edsicos hemodin\u00e1micos e histol\u00f3gicos, convirti\u00e9ndose este m\u00e9todo en el procedimiento a emplar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia de la perfusi\u00f3n normot\u00e9rmica sangu\u00ednea en la preservaci\u00f3n hep\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia de la perfusi\u00f3n normot\u00e9rmica sangu\u00ednea en la preservaci\u00f3n hep\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 I\u00f1igo L\u00f3pez Cenarruzabeitia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cienfuegos \u00e1lvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: daniel Casanova rituerto <\/li>\n<li>Jorge  augusto Quiroga vilas (vocal)<\/li>\n<li>damian Garc\u00eda olmo (vocal)<\/li>\n<li> Monreal marquiegui Jos\u00e9 ignacio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de I\u00f1igo L\u00f3pez Cenarruzabeitia El \u00e9xito que ha supuesto el trasplante en los \u00faltimo a\u00f1os ha revelado la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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