{"id":21703,"date":"2018-03-09T09:11:35","date_gmt":"2018-03-09T09:11:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/eficacia-y-seguridad-de-la-inmunoterapia-con-dermatophagoides-pteronyssinus-en-pauta-acelerada-estudio-doble-ciego\/"},"modified":"2018-03-09T09:11:35","modified_gmt":"2018-03-09T09:11:35","slug":"eficacia-y-seguridad-de-la-inmunoterapia-con-dermatophagoides-pteronyssinus-en-pauta-acelerada-estudio-doble-ciego","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/eficacia-y-seguridad-de-la-inmunoterapia-con-dermatophagoides-pteronyssinus-en-pauta-acelerada-estudio-doble-ciego\/","title":{"rendered":"Eficacia y seguridad de la inmunoterapia con dermatophagoides pteronyssinus en pauta acelerada. estudio doble ciego"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Echechip\u00eda Madoz <\/strong><\/h2>\n<p>Introducci\u00f3n  la pauta convencional de administraci\u00f3n de la inmunoterapia subcut\u00e1nea (it) con extractos alerg\u00e9nicos es lenta en su fase inicial de incremento de dosis hasta alcanzar la dosis de mantenimiento y, aunque resulta segura, supone un gran consumo de tiempo.  objetivos  comparar la eficacia y la seguridad de una pauta de it subcut\u00e1nea con extracto dermatophagoides pteronyssinus (dp) agrupada en 6 semanas en la fase de incremento de dosis con las de la pauta convencional de 12 semanas de duraci\u00f3n.  material y m\u00e9todos  239 pacientes diagnosticados consecutivamente a lo largo de un a\u00f1o de rinitis y\/o asma bronquial al\u00e9rgica por dp con indicaci\u00f3n de it consintieron en particular en el estudio. A 120 se les asign\u00f3 de forma aleatoria la pauta agrupada (x edad 19,34 a\u00f1os y 62,5% hombres) y a 119 la convencional (x edad 18,47 a\u00f1os y 59% hombres). La fase de inicio del tratamiento se administr\u00f3 enmascarando la pauta, agrupada o convencional, de forma doble ciego controlada con placebo, haciendo un registro inform\u00e1tico de las dosis y una graduaci\u00f3n de las reacci\u00f3n adversas. Se evaluaron: la eficacia cl\u00ednica (puntuaci\u00f3n de gravedad cl\u00ednica, registro de cartilla de s\u00edntomas, consumo de medicaci\u00f3n y pef, escala visula anal\u00f3gica y cuestionarios de calidad de vida) y la evoluci\u00f3n de la reactividad cut\u00e1nea a dp (ensayo de l\u00edneas paralelas) antes del inicio de la it, al alcanzar la dosis m\u00e1xima en las pautas agrupada y convencional, y al a\u00f1o de tratamiento.Se determinaron ige, igg total e igg4 espec\u00edficas s\u00e9ricas frente a dp antes de iniciar el tratamiento, cada dos semanas hasta la semana 16 y al a\u00f1o de it.  resultados  no hubo diferencias en las caracter\u00edsticas demogr\u00e1ficas y cl\u00ednicas de los pacientes de ambos grupos. La pauta agrupada redujo en un 46% el tiempo necesario para alcanzar la dosis de mantenimiento, produciendo reacciones adversas sit\u00e9micas, todas leves, en s\u00f3lo un 0,15% inyecciones de tr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Eficacia y seguridad de la inmunoterapia con dermatophagoides pteronyssinus en pauta acelerada. estudio doble ciego<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Eficacia y seguridad de la inmunoterapia con dermatophagoides pteronyssinus en pauta acelerada. estudio doble ciego <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Echechip\u00eda Madoz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isauro Di\u00e9guez L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge  Antonio Guisantes del barco <\/li>\n<li>f\u00e9lix Lorente toledano (vocal)<\/li>\n<li>alfonso Sanchez ibarrola (vocal)<\/li>\n<li>apolinar Lezaun alfonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Echechip\u00eda Madoz Introducci\u00f3n la pauta convencional de administraci\u00f3n de la inmunoterapia subcut\u00e1nea (it) con extractos alerg\u00e9nicos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[13420,65304,14979,65303,17954,65302],"class_list":["post-21703","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-alfonso-sanchez-ibarrola","tag-apolinar-lezaun-alfonso","tag-felix-lorente-toledano","tag-isauro-dieguez-lopez","tag-jorge-antonio-guisantes-del-barco","tag-susana-echechipia-madoz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21703","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21703"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21703\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21703"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21703"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21703"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}