{"id":21728,"date":"2018-03-09T09:11:38","date_gmt":"2018-03-09T09:11:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-ortoquinonas-como-heterodienos-en-la-formacion-de-benzodioxinas-obtencion-de-analogos-del-antitumoral-lapachol-relaciones-estructura-actividad\/"},"modified":"2018-03-09T09:11:38","modified_gmt":"2018-03-09T09:11:38","slug":"estudio-de-ortoquinonas-como-heterodienos-en-la-formacion-de-benzodioxinas-obtencion-de-analogos-del-antitumoral-lapachol-relaciones-estructura-actividad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/la-laguna\/estudio-de-ortoquinonas-como-heterodienos-en-la-formacion-de-benzodioxinas-obtencion-de-analogos-del-antitumoral-lapachol-relaciones-estructura-actividad\/","title":{"rendered":"Estudio de ortoquinonas como heterodienos en la formaci\u00f3n de benzodioxinas. obtenci\u00f3n de an\u00e1logos del antitumoral lapachol: relaciones estructura-actividad"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elisa P\u00e9rez Sacau <\/strong><\/h2>\n<p>La tesis aborda la s\u00edntesis de dos tipos de compuestos bioactivos: la dioxinas y los derivados del producto natural lapachol. En la primera parte se desarrolla un m\u00e9todo para sintetizar dioxinas por medio de una reacci\u00f3n hetero diels alder con demanda inversa de electrones. Se estudian los requerimiento energ\u00e9ticos para que la reacci\u00f3n se lleve a cabo (diferencia de energ\u00eda entre los orbitales homo y lumo, etc.) Y se comenta la importancia biol\u00f3gica de las dioxinas. Es de destacar que es el primer m\u00e9todos \u00fatil para obtener dioxinas polic\u00edclicas.  la segunda parte de la tesis detalla c\u00f3mo es posible modificar la actividad biol\u00f3gica de un producto natural (lapachol) haciendo modificaciones en su estructura. Se estudia la actividad biol\u00f3ica de los derivados (citot\u00f3xica, antimal\u00e1rica, anticolesterol\u00e9mica, etc.) Y al final de cada cap\u00edtulo se resume qu\u00e9 rasgos estructurales son necesarios para que exista una determinada actividad. Algunos derivados presentan una actividad biol\u00f3gica muy interesante, en particular los que presentan actividad antimal\u00e1rica, que no hab\u00eda sido descrita para este tipo de compuestos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de ortoquinonas como heterodienos en la formaci\u00f3n de benzodioxinas. obtenci\u00f3n de an\u00e1logos del antitumoral lapachol: relaciones estructura-actividad<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de ortoquinonas como heterodienos en la formaci\u00f3n de benzodioxinas. obtenci\u00f3n de an\u00e1logos del antitumoral lapachol: relaciones estructura-actividad <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elisa P\u00e9rez Sacau <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Gutierrez Ravelo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julio Gonz\u00e1lez urones <\/li>\n<li>pilar Basabe barcala (vocal)<\/li>\n<li> Ferreira castillo paula cristina (vocal)<\/li>\n<li> Palaz\u00f3n l\u00f3pez Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elisa P\u00e9rez Sacau La tesis aborda la s\u00edntesis de dos tipos de compuestos bioactivos: la dioxinas y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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