{"id":21802,"date":"2018-03-09T09:11:43","date_gmt":"2018-03-09T09:11:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/antipsicoticos-y-autoestimulacion-en-la-corteza-prefrontal-medial-de-la-rata\/"},"modified":"2018-03-09T09:11:43","modified_gmt":"2018-03-09T09:11:43","slug":"antipsicoticos-y-autoestimulacion-en-la-corteza-prefrontal-medial-de-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/antipsicoticos-y-autoestimulacion-en-la-corteza-prefrontal-medial-de-la-rata\/","title":{"rendered":"Antipsic\u00f3ticos y autoestimulaci\u00f3n en la corteza prefrontal medial de la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Hassan Chaatouf El <\/strong><\/h2>\n<p>Se han estudiado los efectos conducturales de diversos antipsic\u00f3ticos que actualmente se usan en el tratamiento farmacol\u00f3gico de la esquizofrenia, una enfermedad mental que por su elevada preValencia, representa un importante problema de salud p\u00fablica en el mundo. Los antipsic\u00f3ticos cl\u00e1sico o t\u00edpicos (at) junto a su acci\u00f3n terap\u00e9utica presentan t\u00edpicamente efectos secundarios motores extrapiramidales (eps). Por el contrario, la clozapina y los nuevos antipsic\u00f3ticos at\u00edpicos (aa), introducidos recientemente en la cl\u00ednica, carecen \u00f3 poseen menor propensi\u00f3n para causar eps. El conocimiento de las bases cient\u00edficas del comportamiento at\u00edpico de este grupo heterog\u00e9neo de compuestos y de sus propiedades diferenciales farmacol\u00f3gicas y conductuales, facilitara el desarrollo futuro de terapias apropiadas.  el objetivo principal de esta tesis ha sido, estudiar los efectos de 2 at y 6 aa y del sch-23390 (un antagonista selectivo de los receptores dopamin\u00e9rgicos d1) sobre la autoestimulaci\u00f3n intracerebral en la corteza prefrontal medial (cpfm) de la rata, prestando especial atenci\u00f3n al patr\u00f3n temporal de respuesta.  los resultados han mostrado que la administraci\u00f3n sist\u00e9mica de at y aa, produce una inhibici\u00f3n del proceso de autoestimulaci\u00f3n. No obstante ambos grupos de f\u00e1rmacos difieren en cuanto al patr\u00f3n temporal de dicha inhibici\u00f3n. As\u00ed, mientras que los at utilizados (haloperidol y pimozida) y el sch-23390 inducen descensos progresivos de la autoestimulaci\u00f3n durante la sesi\u00f3n experimental; los aa no producen estos descensos (clozapina y ziprasidona) o lo hacen con menor intensidad (olanzapina, sertindol, setoperona, risperidona) que los at. El grado del descenso intra-sesi\u00f3n producido por cada droga, podr\u00eda reflejar su grado de atipicidad. Los descensos intra-sesi\u00f3n observados con el sch-23390 sugieren la participaci\u00f3n de los receptores dopamin\u00e9rgicos d1 en dichos descensos. La administraci\u00f3n intracerebral e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Antipsic\u00f3ticos y autoestimulaci\u00f3n en la corteza prefrontal medial de la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Antipsic\u00f3ticos y autoestimulaci\u00f3n en la corteza prefrontal medial de la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Hassan Chaatouf El <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Montes Ram\u00edrez M. I. Rosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tomas Palomo alvarez <\/li>\n<li>Manuel Gurpegui fernandez de legaria (vocal)<\/li>\n<li>Manuel Ramirez sanchez (vocal)<\/li>\n<li>esperanza Del pozo gavil\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Hassan Chaatouf El Se han estudiado los efectos conducturales de diversos antipsic\u00f3ticos que actualmente se usan en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,183,3352,4275,39702,1408],"tags":[65553,65551,18103,3669,65552,6196],"class_list":["post-21802","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-psicotropicos","category-fisiologia-del-sistema-nervioso-central","category-neurociencias","category-neuroquimica","category-psiquiatria","tag-esperanza-del-pozo-gavilan","tag-hassan-chaatouf-el","tag-manuel-gurpegui-fernandez-de-legaria","tag-manuel-ramirez-sanchez","tag-montes-ramirez-m-i-rosa","tag-tomas-palomo-alvarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21802"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21802\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}