{"id":21820,"date":"2018-03-09T09:11:45","date_gmt":"2018-03-09T09:11:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/melanoma-de-extremidades-factores-de-pronostico-clinico-histologico-y-molecular\/"},"modified":"2018-03-09T09:11:45","modified_gmt":"2018-03-09T09:11:45","slug":"melanoma-de-extremidades-factores-de-pronostico-clinico-histologico-y-molecular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/melanoma-de-extremidades-factores-de-pronostico-clinico-histologico-y-molecular\/","title":{"rendered":"Melanoma de extremidades: factores de pronostico clinico, histologico y molecular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ricardo Ruiz Villaverde <\/strong><\/h2>\n<p>Introducci\u00f3n  el melanoma malilgno (mm) constituye un importante problema de salud p\u00fablica. Representa el 3% de las neoplasias malignas de piel y es responsable del 65% de las muertes por \u00e9stas. En la actualidad existen escasas series publicadas sobre los mm de extremidades, localizaci\u00f3n habitualmente no fotoexpuesta y que engloba diferentes formas cl\u00ednicas: melanoma de extensi\u00f3n superficial (mes), melanoma nodular (mn) y melanoma lentiginoso acral (mla) con caracter\u00edsticas cl\u00ednicas, histol\u00f3gicas y evolutivas diferenciadas. recientemente han cambiado los criterios evolutivos en la consideraci\u00f3n del melanoma incidiendo en sus principales factores pron\u00f3sticos; espesor de breslow, ulceraci\u00f3n y afectaci\u00f3n del ganglio.  material y m\u00e9todos  realizamos un estudio observacional retrospectivo que incluye todos los pacientes diagnosticados de mm de extremidades en el periodo comprendido entre 1987 y 1996 para que al menos hubiese un periodo de observaci\u00f3n m\u00ednimo de 5 a\u00f1os, procedentes del territorio de andaluc\u00eda oriental y diagnosticados y tratados en la unidad de melanomas del hospital cl\u00ednico san cecilio de granada. Aplicamos un protocolo de recogida de datos cl\u00ednicos, histol\u00f3gicos (incluyendo t\u00e9cnicas inmunohistoqu\u00edmicas) y moleculares (pcr) para determinar los principales factores de pron\u00f3stico asociados a la aparici\u00f3n de met\u00e1stasis en la muestra objeto de nuestro estudio.  el an\u00e1lisis estad\u00edstico se realiz\u00f3 mediante el paquete estad\u00edstico spss 10.0 para windows, realizando an\u00e1lisis univariante, bivariante y multivariante as\u00ed como estudio comparativo con los melanomas metast\u00e1sicos de la serie de cabeza y cuello, presentada por nuestro grupo con anterioridad en el a\u00f1o 2001.  resultados  la edad media de los pacientes incluidos en la muestra fue de 55,6 a\u00f1os, con predominio de sexo femenino (77,1%). La principal variable objeto de nuestro estudio (aparici\u00f3n de met\u00e1stasis) present\u00f3 asociaciones estad\u00eds<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Melanoma de extremidades: factores de pronostico clinico, histologico y molecular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Melanoma de extremidades: factores de pronostico clinico, histologico y molecular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ricardo Ruiz Villaverde <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvio Serrano Ortega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: david Aguilar pe\u00f1a <\/li>\n<li> Moreno jim\u00e9nez Jos\u00e9 Carlos (vocal)<\/li>\n<li>gines S\u00e1nchez hurtado (vocal)<\/li>\n<li>ricardo Juan Bosch Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ricardo Ruiz Villaverde Introducci\u00f3n el melanoma malilgno (mm) constituye un importante problema de salud p\u00fablica. Representa el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,97,52,156],"tags":[3690,65595,3675,41037,65594,3671],"class_list":["post-21820","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-dermatologia","category-histopatologia","category-patologia","tag-david-aguilar-pena","tag-gines-sanchez-hurtado","tag-moreno-jimenez-jose-carlos","tag-ricardo-juan-bosch-garcia","tag-ricardo-ruiz-villaverde","tag-salvio-serrano-ortega"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21820","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21820"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21820\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}