{"id":21824,"date":"2018-03-09T09:11:46","date_gmt":"2018-03-09T09:11:46","guid":{"rendered":""},"modified":"2018-03-09T09:11:46","modified_gmt":"2018-03-09T09:11:46","slug":"activacion-del-calcio-intracelular-y-de-las-protea%c2%adnas-quinasas-reguladas-por-senales-extracelulares-por-estimulacion-de-los-receptores-muscara%c2%adnicos-en-celulas-epiteliales-tiroideas-frt","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/activacion-del-calcio-intracelular-y-de-las-protea%c2%adnas-quinasas-reguladas-por-senales-extracelulares-por-estimulacion-de-los-receptores-muscara%c2%adnicos-en-celulas-epiteliales-tiroideas-frt\/","title":{"rendered":"Activaci\u00f3n del calcio intracelular y de las prote\u00ednas quinasas reguladas por se\u00f1ales extracelulares por estimulaci\u00f3n de los receptores muscar\u00ednicos en c\u00e9lulas epiteliales tiroideas frt"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Idoia Gamez Mu\u00f1oz <\/strong><\/h2>\n<p>La funci\u00f3n de las c\u00e9lulas tiroideas est\u00e1 regulada principalmente mediante dos cascadas de se\u00f1alizaci\u00f3n intracelular, el sistema adenilato ciclasa-camp y el sistema fosfatidilinositol-ca2+, que se desencadenan por la activaci\u00f3n de receptores espec\u00edficos localizados en la membrana plasm\u00e1tica de los tirocitos.  en el presente estudio demostramos que la estimulaci\u00f3n de los receptores de acetilcolina muscar\u00ednicos presentes en la membrana plasm\u00e1tica de las c\u00e9lulas epiteliales tiroideas frt est\u00e1n acoplados funcionalmente a prote\u00ednas gq heterotrim\u00e9ricas, de manera que su estimulaci\u00f3n produce un aumento bif\u00e1sico en la movilizaci\u00f3n del calcio libre intracelular, con una fase inicial mediada principalmente por la activaci\u00f3n de la fosfolipasa c y una segunda fase estacionaria debida a una entrada del calcio extracelular a trav\u00e9s de canales de calcio voltaje dependientes y al influjo del i\u00f3n por v\u00eda capacitativa. Sin embargo, estos receptores muscar\u00ednicos, predominantemente del subtipo m3, no est\u00e1n asociados a prot\u00ednas gs o gi reguladoras de la activaci\u00f3n adenilato ciclasa, aunque nuestros datos indican la existencia de un mecanismo de entrecruzamiento de se\u00f1ales entre la concentraci\u00f3n de camp y la actividad de la fosfolipasa c para regular la concentraci\u00f3n del calcio intracelular.  la estimulaci\u00f3n de los receptores muscar\u00ednicos por carbacol, un an\u00e1logo de la acetilcolina, produce adem\u00e1s un incremento, tiempo y dosis dependiente, en la fosforilaci\u00f3n de las quinasas reguladas por se\u00f1ales extracelulares 1\/2 en estas c\u00e9lulas tiroideas. La activaci\u00f3n de esta cascada de las prote\u00ednas quinasas activadas por mit\u00f3genos depende, al menos en parte, de la activaci\u00f3n de la fosfolipasa c, de la movilizaci\u00f3n del calcio intracelular, de la calcio calmodulina (cam), de la fosfatidilinositol 3-quinasa y de la familia de tirosinas quinasas src, pero es independiente de la prote\u00edna quinasa c. As\u00ed mismo, los receptores muscar\u00ed<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Activaci\u00f3n del calcio intracelular y de las prote\u00ednas quinasas reguladas por se\u00f1ales extracelulares por estimulaci\u00f3n de los receptores muscar\u00ednicos en c\u00e9lulas epiteliales tiroideas frt<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Activaci\u00f3n del calcio intracelular y de las prote\u00ednas quinasas reguladas por se\u00f1ales extracelulares por estimulaci\u00f3n de los receptores muscar\u00ednicos en c\u00e9lulas epiteliales tiroideas frt <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Idoia Gamez Mu\u00f1oz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mercedes Montiel Leyva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell oca\u00f1a <\/li>\n<li>Jos\u00e9 f\u00e9lix Vargas palomares (vocal)<\/li>\n<li>Francisco Solano mu\u00f1oz (vocal)<\/li>\n<li>Jos\u00e9 Pov\u00eda molina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Idoia Gamez Mu\u00f1oz La funci\u00f3n de las c\u00e9lulas tiroideas est\u00e1 regulada principalmente mediante dos cascadas de se\u00f1alizaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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