{"id":21850,"date":"2018-03-09T09:11:48","date_gmt":"2018-03-09T09:11:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-que-influyen-sobre-el-injerto-en-el-trasplante-autologo-de-progenitores-hematopoyeticos-de-sangre-periferica\/"},"modified":"2018-03-09T09:11:48","modified_gmt":"2018-03-09T09:11:48","slug":"factores-que-influyen-sobre-el-injerto-en-el-trasplante-autologo-de-progenitores-hematopoyeticos-de-sangre-periferica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-que-influyen-sobre-el-injerto-en-el-trasplante-autologo-de-progenitores-hematopoyeticos-de-sangre-periferica\/","title":{"rendered":"Factores que influyen sobre el injerto en el trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos de sangre perif\u00e9rica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier P\u00e9rez Calvo <\/strong><\/h2>\n<p>Los resultados del trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos vienen condicionados de forma importante por la precocidad con que se consigue el injerto hematopoy\u00e9tico tras la infusi\u00f3n celular. El objetivo de este trabajo es dilucidar los factores que condicionan la precodidad de dicho injerto estudiando con especial detenimiento la dosis de c\u00e9lulas progenitoras: la comparaci\u00f3n de distintas estrategias para su estimaci\u00f3n, la viabilidad del trasplante con una dosis baja, la posibilidad de predecir la dosis recolectada y el estudio de los factores que condicionan su movilizaci\u00f3n a sangre perif\u00e9rica tras un tratamiento con filgrastim. Para ello se estudia una serie de 211 trasplantes consecutivos realizados a pacientes con distintos tumores s\u00f3lidos y hematol\u00f3gicos. Mediante modelos de an\u00e1lisis de riesgos proporcionales se analizan la influencia de 37 par\u00e1metros diferentes sobre los tiempos de recuperaci\u00f3n granuloc\u00edtica y plaquetar postrasplante y sobre el consumo de hemoderivados.  asimismo, se utilizan t\u00e9cnicas de correlaci\u00f3n no par\u00e1metricas y de regresi\u00f3n lienal m\u00faltiple para estudiar la estimaci\u00f3n de la dosis celular y la movilizaci\u00f3n. la dosis de c\u00e9lulas cd34+\/33- result\u00f3 ser el par\u00e1metro con mayor influencia sobre la recuperaci\u00f3n granuloc\u00edtica y plaquetar en el an\u00e1lisis multivariante.  la dosis de cfu-gm, la presencia de enfermedad extramedular y el diagn\u00f3stico tambi\u00e9n influyeron significativamente sobre la recuperaci\u00f3n granuloc\u00edtica, y el volumen de tratamiento previo recibido y la remisi\u00f3n completa pretrasplante sobre la recuperaci\u00f3n de plaquetas. La dosis de c\u00e9lulas cd34+\/33- result\u00f3 ser el par\u00e1metro m\u00e1s eficaz de los estudiados para estimar la dosis de progenitories hematopoy\u00e9ticos. La dosis ideal recomendable es 2,5 x 10(6)\/kg o m\u00e1s, aunque dosis comprendidas entre 1 y 2,5 x 10(6)\/kg consiguen resultados aceptables para pacientes en que la recolecci\u00f3n sea dif\u00edcil. El recuento de c\u00e9<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores que influyen sobre el injerto en el trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos de sangre perif\u00e9rica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores que influyen sobre el injerto en el trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos de sangre perif\u00e9rica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier P\u00e9rez Calvo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Villegas Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li>ines Torres mart\u00ednez (vocal)<\/li>\n<li> D\u00edez mart\u00edn Jos\u00e9 Luis (vocal)<\/li>\n<li>Jaime Jimenez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier P\u00e9rez Calvo Los resultados del trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos vienen condicionados de forma importante por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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