{"id":21853,"date":"2018-03-09T09:11:48","date_gmt":"2018-03-09T09:11:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-cardiovasculares-del-tratamiento-cronico-con-terazosina-en-ratas-espontaneamente-hipertensas\/"},"modified":"2018-03-09T09:11:48","modified_gmt":"2018-03-09T09:11:48","slug":"efectos-cardiovasculares-del-tratamiento-cronico-con-terazosina-en-ratas-espontaneamente-hipertensas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/efectos-cardiovasculares-del-tratamiento-cronico-con-terazosina-en-ratas-espontaneamente-hipertensas\/","title":{"rendered":"Efectos cardiovasculares del tratamiento cr\u00f3nico con terazosina en ratas espont\u00e1neamente hipertensas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noelia Ardanaz Mart\u00ednez <\/strong><\/h2>\n<p>Se investig\u00f3 en ratas espont\u00e1neamente hipertensas el efecto del tratamiento cr\u00f3nico con terazosina sobre las alteraciones cardiovasculares que se presentan en la hipertensi\u00f3n arterial.  se establecieron tratamientos a medio (2 meses) y largo plazo (6 meses) con 0,5 y 10 mg\/kg\/d\u00eda de terazosina. Un grupo de ratas espont\u00e1neamente hipertensas y otro de ratas normontensas sin tratamiento fueron utilizados como controles. Un tercer periodo de estudio se estableci\u00f3 para determinar si los efectos durante 6 meses de tratamiento se manten\u00edan tres meses despu\u00e9s de suprimir la administraci\u00f3n del f\u00e1rmaco.  la eficacia antihipertensiva se control\u00f3 midiendo la presi\u00f3n arterial sist\u00f3lica y frecuencia cardiaca por el m\u00e9todo incruento de medida en la cola. Finalizados los tratamientos se realizaron estudios de funcionalidad en anillos de arteria aorta y lecho vascular mesent\u00e9rico perfundido y se procesaron muestras de aorta y coraz\u00f3n para realizar estudios morfom\u00e9tricos y de fibrosis.  el tratamiento con 10 mg\/kg\/d\u00eda de terazosina redujo los valores de presi\u00f3n arterial sist\u00f3lica de forma significativa, efecto que se mantiene parcialmente incluso tras la retirada del f\u00e1rmaco. No existieron cambios significativos con respecto al grupo control con la dosis de 0,5 mg\/kg\/d\u00eda. La dosis de 10 mg\/kg\/d\u00eda produjo un aumento de sensibilidad a noradrenalina que parece ser debido a cambios en el receptor alfa1b-adren\u00e9rgico. El tratamiento durante seis meses, mejor\u00f3 la respuesta vascular a acetilcolina en arteria aorta. A nivel histol\u00f3gico se observ\u00f3 una disminuci\u00f3n del grosor de la capa media de la arteria aorta con la dosis de 10 mg\/kg\/d\u00eda a largo plazo que se mantienen tres meses despu\u00e9s de retirar el f\u00e1rmaco. Ambas dosis reducen la deposici\u00f3n de  col\u00e1geno en arteria aorta efecto que contin\u00faa 3 meses despu\u00e9s de retirar el tratamiento.  el tratamiento produce una reducci\u00f3n de la hipertrofia ventricular izquierda y de la deposic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos cardiovasculares del tratamiento cr\u00f3nico con terazosina en ratas espont\u00e1neamente hipertensas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos cardiovasculares del tratamiento cr\u00f3nico con terazosina en ratas espont\u00e1neamente hipertensas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noelia Ardanaz Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/02\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jose Montero G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mercedes Salaices s\u00e1nchez <\/li>\n<li>Mar\u00eda  dolores Ivorra insa (vocal)<\/li>\n<li> Ar\u00e9valo g\u00f3mez Miguel \u00e1ngel (vocal)<\/li>\n<li> Mart\u00edn calvo Mar\u00eda Luisa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noelia Ardanaz Mart\u00ednez Se investig\u00f3 en ratas espont\u00e1neamente hipertensas el efecto del tratamiento cr\u00f3nico con terazosina sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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