{"id":21937,"date":"2003-06-03T00:00:00","date_gmt":"2003-06-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analogos-de-prostaglandinas-en-el-tratamiento-del-glaucoma\/"},"modified":"2003-06-03T00:00:00","modified_gmt":"2003-06-03T00:00:00","slug":"analogos-de-prostaglandinas-en-el-tratamiento-del-glaucoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/alcala\/analogos-de-prostaglandinas-en-el-tratamiento-del-glaucoma\/","title":{"rendered":"Analogos de prostaglandinas en el tratamiento del glaucoma."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Esther Arranz Marquez <\/strong><\/h2>\n<p>Los an\u00e1logos de la prostaglandina f2a, entre los que se incluye el latanoprost, son los agentes hipotensores de m\u00e1s reciente generaci\u00f3n en el tratamiento del glaucoma. Se han destacado por presentar un efecto hipotensor medio potente, junto con un novedoso mecanismo de actuaci\u00f3n: el aumento de drenaje del humor acuoso por la v\u00eda uveoescleral. Se acompa\u00f1an, como efecto adverso m\u00e1s caracter\u00edstico, de un incremento en la pigmentaci\u00f3n  del iris de algunos de los pacientes tratados.Pretendemos estudiar el comportamiento de la presi\u00f3n intraocular (pio), as\u00ed como los efectos adversos asociados con la aplicaci\u00f3n t\u00f3pica del latanoprost 0,005% en pacientes glaucomatosos. para ello llevamos a cabo un estudio en 214 pacientes, en tratamiento con dicho f\u00e1rmaco una vez al d\u00eda, en los que se realiz\u00f3, adem\u00e1s de una exploraci\u00f3n oftalmol\u00f3gica completa, un registro de su pio, biometr\u00eda ocular, control fotogr\u00e1fico del iris, an\u00e1lisis histol\u00f3gico de iris con cambio de color y pruebas de funci\u00f3n pulmonar en pacientes afectos de enfermedad pulmonar obstructiva cr\u00f3nica (epoc).Como conclusiones principales se destacan las siguientes: el latanoprost presenta un efecto hipotensor potente y mantenido en el tiempo, aunque la respuesta es heterog\u00e9nea dentro de la poblaci\u00f3n estudiada. Los ojos con mayores pio de partida y menores longitudes axiales presentan mejor respuesta hipotensora al f\u00e1rmaco. La pilocarpina tiene un efecto variable sobre la pio en ojos tratados con latanoprost, y \u00e9ste presenta un menor efecto cuando se aplica en ojos sometidos previamente a una trabeculoplastia l\u00e1ser arg\u00f3n (tla). Encontramos una alta incidencia de cambio de color de iris en respuesta al tratamiento, que parece ser mayor a edades m\u00e1s avanzadas, y dos patrones distintos de pigmentaci\u00f3n; adem\u00e1s, estos iris presentan m\u00e1s alteraciones estructurales que un simple aumento de melanina en el interior de sus melanocitos. A nivel sist\u00e9mico, el tratamiento cr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analogos de prostaglandinas en el tratamiento del glaucoma.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analogos de prostaglandinas en el tratamiento del glaucoma. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Esther Arranz Marquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Teus Guezala<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio L\u00f3pez alonso <\/li>\n<li>alfonso Anton lopez (vocal)<\/li>\n<li>Juli\u00e1n Garcia feijoo (vocal)<\/li>\n<li>Ana Boto de los bueis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Esther Arranz Marquez Los an\u00e1logos de la prostaglandina f2a, entre los que se incluye el latanoprost, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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