{"id":21957,"date":"2003-07-03T00:00:00","date_gmt":"2003-07-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-estructural-y-funcional-de-genes-relacionados-con-la-sa%c2%adntesis-y-degradacion-de-trehalosa-en-schizosaccharomyces-pombe\/"},"modified":"2003-07-03T00:00:00","modified_gmt":"2003-07-03T00:00:00","slug":"analisis-estructural-y-funcional-de-genes-relacionados-con-la-sa%c2%adntesis-y-degradacion-de-trehalosa-en-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/analisis-estructural-y-funcional-de-genes-relacionados-con-la-sa%c2%adntesis-y-degradacion-de-trehalosa-en-schizosaccharomyces-pombe\/","title":{"rendered":"An\u00e1lisis estructural y funcional de genes relacionados con la s\u00edntesis y degradaci\u00f3n de trehalosa en schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alejandro Franco S\u00e1nchez <\/strong><\/h2>\n<p>La trehalosa se caracteriza por ser un disac\u00e1rido no reductor, formado por dos mol\u00e9culas de glucosa que en levaduras desempe\u00f1a funciones vitales, no solo como metabolito energ\u00e9tico sino tambi\u00e9n como metabolito de respuesta a estr\u00e9s, acumul\u00e1ndose en tales circunstancias. En la levadura con fisi\u00f3n schizosaccharomyces pombe, la trehalosa esta sometida a una estricta regulaci\u00f3n tanto en su bios\u00edntesis como en su hidr\u00f3lisis a trav\u00e9s de v\u00edas de se\u00f1alizaci\u00f3n intracelular (map kinasas y pka1\/sck1), dichas v\u00edas act\u00faan a nivel transcripcional y postraduccional. Hasta el presente trabajo se conoc\u00edan los genes responsables de la s\u00edntesis de trehalosa-6-p (metabolito intermediario) tps1+ (trehalosa-6-p sintetasa) y de la hidr\u00f3lisis de trehalosa ntp1+ (trehalasa neutra). En este trabajo hemos clonado y caracterizado el gen responsable de la actividad trehalosa-6-p fosfatasa principal de la levadura con fisi\u00f3n (tpp1+). Cuando se interrumpi\u00f3 el gen observamos acumulaci\u00f3n de trehalosa-6-p detectable mediante tlc, adem\u00e1s de igual manera que ocurre en saccharomyces cerevisiae, las c\u00e9lulas mutadas manifestaron crecimiento termosensible, mostrando un estacionamiento prematuro de su crecimiento. A nivel de regulaci\u00f3n transcripcional mostr\u00f3 una clara inducci\u00f3n de la expresi\u00f3n en respuesta a choque t\u00e9rmico y osm\u00f3tico estando en este \u00faltimo caso regulada por la ruta de map kinasas cuyo elemento principal en la map kinasa sty1p. El conjunto de resultados muestran un estricto mecanismo de regulaci\u00f3n no solo a nivel transcripcional sino tambi\u00e9n postrancripcional y\/o traduccional, as\u00ed como mecanismos compartidos con los genes tps1+ y ntp1+. Otro aspecto que se abord\u00f3 fue la descripci\u00f3n de interacciones entre las prote\u00ednas responsables de la s\u00edntesis e hidr\u00f3lisis de trehalosa existiendo un complejo multienzim\u00e1tico en el que participan tps1p, tpp1p y ntp1p, aunque la forma activada de trehalasa neutra (ntp 1p) no interviene en dich<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis estructural y funcional de genes relacionados con la s\u00edntesis y degradaci\u00f3n de trehalosa en schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis estructural y funcional de genes relacionados con la s\u00edntesis y degradaci\u00f3n de trehalosa en schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alejandro Franco S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Gacto Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Gonz\u00e1lez villa <\/li>\n<li>yolanda Sanchez martin (vocal)<\/li>\n<li>Jorge Barros vel\u00e1zquez (vocal)<\/li>\n<li>jeronima Vicente soler (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alejandro Franco S\u00e1nchez La trehalosa se caracteriza por ser un disac\u00e1rido no reductor, formado por dos mol\u00e9culas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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