{"id":2197,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/estudio-farmacocinetico-del-luxabendazol-en-conejo\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"estudio-farmacocinetico-del-luxabendazol-en-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacocinetico-del-luxabendazol-en-conejo\/","title":{"rendered":"Estudio farmacocinetico del luxabendazol en conejo"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Alvarez Bujidos M. Lucia <\/strong><\/h2>\n<p>El luxabendazol es un antihelmintico de estructura benzimidazolica recientemente sintetizado por los laboratorios hoechcst. Se ha desarrollado un metodo de deteccion y cuantificacion para este farmaco en fluidos biologicos mediante hplc que permitio un estudio de la evolucion de los niveles plamaticos frente al tiempo tras su administracion por distintas vias. Se ha realizado un estudio farmacocinetico del luxabendazol en conejo como especie de referencia tras su administracion por via oral e intravenosa comprobandose que en ambos casos se dan procesos de reabsorcion intestinal del producto excretado por bilis a intestino. Estos procesos de reabsorcion intestinal producen un claro aumento de la biodisponibilidad determinada para la administracion oral tanto en disolucion como en suspension respecto al valor calculado en animales con ciclo enterohepatico interrumpido. Se realizo posteriormente un estudio de la union de luxabendazol a proteinas plasmaticas, el porcentaje de union a protinas plasmaticas totales fue de 38,85% y para la albumina de plasma de 32,94%. El lbz se une a la albumina en dos clases de sitios de union distintos e independientes, uno de alta afinidad y baja capacidad y otro de baja afinidad y alta capacidad. De los valores energeticos hallados para esta union se postula que concurren dos tipos de union ionica e hidrofobica siendo la primera la que facilita la segunda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocinetico del luxabendazol en conejo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocinetico del luxabendazol en conejo <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Alvarez Bujidos M. Lucia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Ordo\u00f1ez Escudero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Cadorniga Carro <\/li>\n<li>Jos\u00e9 Martinez Lanao (vocal)<\/li>\n<li>Diego Santiago Laguna (vocal)<\/li>\n<li>Rafael Bala\u00f1a Fouce (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvarez Bujidos M. Lucia El luxabendazol es un antihelmintico de estructura benzimidazolica recientemente sintetizado por los laboratorios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,9386,401],"tags":[9409,4565,9411,9410,9412,342],"class_list":["post-2197","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-salamanca","category-toxicologia","tag-alvarez-bujidos-m-lucia","tag-david-ordonez-escudero","tag-diego-santiago-laguna","tag-jose-Martinez-lanao","tag-rafael-balana-fouce","tag-rafael-cadorniga-carro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=2197"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/2197\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=2197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=2197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=2197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}