{"id":21979,"date":"2003-07-03T00:00:00","date_gmt":"2003-07-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-un-modelo-transgenico-de-diabetes-autoinmune-papel-de-la-expresion-pancreatica-de-igf-i-en-la-prevencion-de-la-respuesta-inflamatoria\/"},"modified":"2003-07-03T00:00:00","modified_gmt":"2003-07-03T00:00:00","slug":"caracterizacion-de-un-modelo-transgenico-de-diabetes-autoinmune-papel-de-la-expresion-pancreatica-de-igf-i-en-la-prevencion-de-la-respuesta-inflamatoria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-un-modelo-transgenico-de-diabetes-autoinmune-papel-de-la-expresion-pancreatica-de-igf-i-en-la-prevencion-de-la-respuesta-inflamatoria\/","title":{"rendered":"Caracterizaci\u00f3n de un modelo transg\u00e9nico de diabetes autoinmune. papel de la expresi\u00f3n pancre\u00e1tica de igf-i en la prevenci\u00f3n de la respuesta inflamatoria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alba Casellas Comallonga <\/strong><\/h2>\n<p>La diabetes tipo 1 es el resultado de la destrucci\u00f3n autoinmune de las c\u00e9lulas beta pancre\u00e1ticas. En islotes de pacientes diab\u00e9ticos tipo 1 se ha detectado la presencia de interfer\u00f3n beta (ifnbeta). Ratones transg\u00e9nicos que expresan  ifnbeta humano en las c\u00e9lulas beta obteniendo en nuestro laboratorio presentan alterada la secreci\u00f3n de insulina y son m\u00e1s susceptibles a desarrollar diabetes. Estos ratones presentan una buena viabilidad y se reproducen con facilidad. Tras la administraci\u00f3n de dosis muy bajas de stz (15-20 mg\/kg peso), que no afectan a los ratones control, los ratones transg\u00e9nicos presentan un incremento cr\u00f3nico de la gluc\u00e9mia y una gran infiltraci\u00f3n linfocitaria en sus islotes, con presencia de linfocitos t cd4+ y cd8+. Esto lleva a la destrucci\u00f3n de las c\u00e9lulas beta por un proceso apopt\u00f3tico. Los resultados indican que los ratones transg\u00e9nicos que expresan ifnbeta en c\u00e9lulas beta podr\u00edan ser un buen modelo para desarrollar protocolos de terapia g\u00e9nica o de terapias convencionales para la diabetes tipo 1.  el factor de creimiento similar a la insulina de tipo i (igf-i) estimula la proliferaci\u00f3n y la diferenciaci\u00f3n de las c\u00e9lulas beta y es un potente fator antiapopt\u00f3tico. Ratones transg\u00e9nicos que expresan igf-i espec\u00edficamente en las c\u00e9lulas beta del p\u00e1ncreas (rip\/igf-i), obtenidos en nuestro laboratorio, presentan una recuperaci\u00f3n en la masa de c\u00e9lulas beta despu\u00e9s de la inducci\u00f3n de diabetes experimental mediante tratamiento con stz. Con el objetivo de determinar el papel de igf-i en la contrarrestaci\u00f3n de la diabetes autoinmune hemos generado animales dobles transg\u00e9nicos ifnbeta\/igf-i. Los resultados indican que la producci\u00f3n local de igf-i protege a las c\u00e9lulas beta de la destrucci\u00f3n mediada por el sistema inmune y contrarresta la diabetes experimental inducida por stz, nomalizandose la glucemia, insulinemia y la masa de c\u00e9lulas beta. Por tanto, la transferencia del gen igf-i a p\u00e1ncr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de un modelo transg\u00e9nico de diabetes autoinmune. papel de la expresi\u00f3n pancre\u00e1tica de igf-i en la prevenci\u00f3n de la respuesta inflamatoria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de un modelo transg\u00e9nico de diabetes autoinmune. papel de la expresi\u00f3n pancre\u00e1tica de igf-i en la prevenci\u00f3n de la respuesta inflamatoria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alba Casellas Comallonga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fatima Bosch Tubert<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Ari\u00f1o <\/li>\n<li>Marta Vives (vocal)<\/li>\n<li>conchi Mora (vocal)<\/li>\n<li>lisardo Bosca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alba Casellas Comallonga La diabetes tipo 1 es el resultado de la destrucci\u00f3n autoinmune de las c\u00e9lulas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[65983,65985,14073,9031,17566,65984],"class_list":["post-21979","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-alba-casellas-comallonga","tag-conchi-mora","tag-fatima-bosch-tubert","tag-joaquin-arino","tag-lisardo-bosca","tag-marta-vives"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=21979"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/21979\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=21979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=21979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=21979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}