{"id":22005,"date":"2003-10-03T00:00:00","date_gmt":"2003-10-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategias-terapeuticas-anti-inflamatorias-en-un-modelo-experimental-de-esclerosis-multiple\/"},"modified":"2003-10-03T00:00:00","modified_gmt":"2003-10-03T00:00:00","slug":"estrategias-terapeuticas-anti-inflamatorias-en-un-modelo-experimental-de-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estrategias-terapeuticas-anti-inflamatorias-en-un-modelo-experimental-de-esclerosis-multiple\/","title":{"rendered":"Estrategias terap\u00e9uticas anti-inflamatorias en un modelo experimental de esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00e1ngel Luis Ar\u00e9valo Mart\u00edn <\/strong><\/h2>\n<p>En el modelo de infecci\u00f3n por el virus de theiler, hemos observado una mejora en la coordinaci\u00f3n motora, una disminuci\u00f3n de las c\u00e9lulas t infiltradas en el sistema nervioso central y una disminuci\u00f3n de la reactividad microglial en los animales tratados con el virus de theiler. La acci\u00f3n anti-inflamatoria y de recuperaci\u00f3n funcional de los cannabinoides se mantiene en el tiempo hasta, al menos, 25 d\u00edas despu\u00e9s de haber finalizado el tratamiento. Adem\u00e1s, a los 25 d\u00edas de haber acabado el tratamiento se observ\u00f3 una remielinizaci\u00f3n del sistema nervioso central de los animales tratados con compuestos cannabinoides. para discernir si esta remielinizaci\u00f3n era consecuencia exclusivamente de disminuir el ambiente inflamatorio o si tambi\u00e9n ten\u00eda lugar un efecto directo de los cannabionoides sobre las c\u00e9lulas oligodendrogliales se llev\u00f3 a cabo una serie de experimentos con cultivos primarios de oligodendrocitos de rata. Observamos que los oligodendrocitos expresan receptores de cannabionoides y en un modelo de muerte celular por privaci\u00f3n de soporte tr\u00f3fico, los cannabinoides eran capaces de promover la supervivencia de estas c\u00e9lulas al inhibir la apoptosis. Este proceso, adem\u00e1s, est\u00e1 mediado pro la activaci\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n celular de la pi3k\/akt.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estrategias terap\u00e9uticas anti-inflamatorias en un modelo experimental de esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estrategias terap\u00e9uticas anti-inflamatorias en un modelo experimental de esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00e1ngel Luis Ar\u00e9valo Mart\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Guaza Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>teresa Iglesias vacas (vocal)<\/li>\n<li>augusto Silva gonzalez (vocal)<\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1ngel Luis Ar\u00e9valo Mart\u00edn En el modelo de infecci\u00f3n por el virus de theiler, hemos observado una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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