{"id":22030,"date":"2003-11-03T00:00:00","date_gmt":"2003-11-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-gluconeogenesis-hepatica-por-leptina-y-va%c2%adas-de-senalizacion-implicadas-en-la-induccion-de-la-expresion-del-gen-de-la-glucokinasa-hepatica-por-insulina\/"},"modified":"2003-11-03T00:00:00","modified_gmt":"2003-11-03T00:00:00","slug":"regulacion-de-la-gluconeogenesis-hepatica-por-leptina-y-va%c2%adas-de-senalizacion-implicadas-en-la-induccion-de-la-expresion-del-gen-de-la-glucokinasa-hepatica-por-insulina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-gluconeogenesis-hepatica-por-leptina-y-va%c2%adas-de-senalizacion-implicadas-en-la-induccion-de-la-expresion-del-gen-de-la-glucokinasa-hepatica-por-insulina\/","title":{"rendered":"Regulaci\u00f3n de la gluconeog\u00e9nesis hep\u00e1tica por leptina y v\u00edas de se\u00f1alizaci\u00f3n implicadas en la inducci\u00f3n de la expresi\u00f3n del gen de la glucokinasa hep\u00e1tica por insulina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andr\u00e9s Esteban Gamboa <\/strong><\/h2>\n<p>Los efectos metab\u00f3licos ejercidos por la leptina en tejidos extraneurales presentan cierta controversia, habi\u00e9ndose descrito acciones \u00absimilares a las de la insulina\u00bb y acciones \u00abanti-insulina\u00bb. En la primera parte de este trabajo, estudiamos la posible modulaci\u00f3n a corto y largo plazo de la gluconeog\u00e9nesis por leptina. La leptina no modific\u00f3 a corto plazo la gluconeog\u00e9nesis a partir de lactato, ni el estado de activaci\u00f3n de la piruvato kinasa l (pk-l), ni los niveles de fructosa 2,6-bifosfato (f-2,6-p2), en hepatocitos aislados de rata. Sin embargo, esta citokina fue capaz de antagonizar la reducci\u00f3n de la gluconeog\u00e9nesis provocada por la insulina, aunque de nuevo sin provocar cambios en el estado de activaci\u00f3n de la pk-l ni en los niveles celulares de f-2,6-p2. Por otro lado, el tratamiento de hepatocitos cultivados a largo plazo con leptina aument\u00f3 la gluconeog\u00e9nesis desde lactato, as\u00ed como los niveles de mrna y la actividad de la glucosa 6-fosfatasa (g6pasa).  adem\u00e1s, la leptina antagoniz\u00f3 la reducci\u00f3n ejercida por la insulina sobre la gluconeog\u00e9nesis y tambi\u00e9n sobre los niveles de mrna y de actividad de la fosfoenolpiruvato carboxikinasa (pepck) y de la g6pasa. No obstante, en hepatocitos cultivados tratados con dibutiril-amp c\u00edclico, la leptina s\u00f3lo fue capaz de antagonizar la reducci\u00f3n en los niveles de mrna de la pepck y de la g6pasa causada por la insulina de un modo transitorio.  este efecto transitorio de la leptina pareci\u00f3 deberse a la coincidencia temporal de dos fen\u00f3menos: un aumento en la vida media de ambos mrnas por la presencia conjunta de leptina y de insulina en el medio de incubaci\u00f3n, y la r\u00e1pida desaparici\u00f3n de estos mrnas en los hepatocitos cultivados, independientemente de la variable ensayada.  en la segunda parte de este trabajo, nos propusimos estudiar las v\u00edas de se\u00f1alizaci\u00f3n responsables de la inducci\u00f3n de la expresi\u00f3n del mrna de la glucokinasa (gk) por insulina, en hepatocito<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la gluconeog\u00e9nesis hep\u00e1tica por leptina y v\u00edas de se\u00f1alizaci\u00f3n implicadas en la inducci\u00f3n de la expresi\u00f3n del gen de la glucokinasa hep\u00e1tica por insulina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la gluconeog\u00e9nesis hep\u00e1tica por leptina y v\u00edas de se\u00f1alizaci\u00f3n implicadas en la inducci\u00f3n de la expresi\u00f3n del gen de la glucokinasa hep\u00e1tica por insulina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andr\u00e9s Esteban Gamboa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Emilio Feliu Albi\u00f1ana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Gonz\u00e1lez casta\u00f1o <\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<li>enrique Bl\u00e1zquez fern\u00e1ndez (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Iraburu elizalde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Esteban Gamboa Los efectos metab\u00f3licos ejercidos por la leptina en tejidos extraneurales presentan cierta controversia, habi\u00e9ndose [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[66115,3180,29709,14572,5664,41611],"class_list":["post-22030","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-andres-esteban-gamboa","tag-enrique-blazquez-fernandez","tag-jose-gonzalez-castano","tag-juan-emilio-feliu-albinana","tag-lisardo-bosca-gomar","tag-maria-jose-iraburu-elizalde"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22030"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22030\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}