{"id":22039,"date":"2003-12-03T00:00:00","date_gmt":"2003-12-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-protonacion-enantioselectiva-de-enolatos-en-condiciones-catala%c2%adticas-y-estequiometricas\/"},"modified":"2003-12-03T00:00:00","modified_gmt":"2003-12-03T00:00:00","slug":"estudio-de-la-protonacion-enantioselectiva-de-enolatos-en-condiciones-catala%c2%adticas-y-estequiometricas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-protonacion-enantioselectiva-de-enolatos-en-condiciones-catala%c2%adticas-y-estequiometricas\/","title":{"rendered":"Estudio de la protonaci\u00f3n enantioselectiva de enolatos en condiciones catal\u00edticas y estequiom\u00e9tricas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gil Tom\u00e1s Jes\u00fas Javier <\/strong><\/h2>\n<p>Objetivos  cap\u00edtulo 1  1,- preparaci\u00f3n de 1,2-sulfinil alcoholes quirales mediante una secuencia de dos pasos.  2,- preparaci\u00f3n de derivados de la (-)-(1r, 2s)-efedrina y d ela (-)-(1r, 2s)-norefedrina.  3,- protonaci\u00f3n enantioselectiva sobreestequimom\u00e9trica interna de enolatos de cetona con 1,2-sulfonil alcoholes quirales.  4,- protonaci\u00f3n enantioselectiva sobrestequiom\u00e9trica interna, externa y de tipo ipr de enolatos de morfolinona con 1,2-sulfinil alcoholes quirale sy derivados de catecolaminas quirales.  cap\u00edtulo 2  1,- protonaci\u00f3n enantioselectiva interna del enolato de la 2-metil-1-tetralona con los 1,2-sulfinil alcoholes 3a y 3e en condiciones catal\u00edticas y subestequiom\u00e9tricas son generaci\u00f3n del enolato desde el inicio de la reacci\u00f3n (m\u00e9todo a).  2,- protonaci\u00f3n enantioselectiva interna del enolato de la 2-metil -1-tetralona con el 1,2-sulfinil alcohol 3a en condiciones catal\u00edticas y subestequiom\u00e9tricas con generaci\u00f3n lenta del enolato (m\u00e9todo b).  3,- discusi\u00f3n del mecanismo de la reacci\u00f3n (m\u00e9todo b).  conclusiones  cap\u00edtulo 1  1,- la protonaci\u00f3n enantioselectiva sobreestequiom\u00e9trica deinterna de enolatos de la 2-alquilcicloalcanonas con el 1,2-sulfinil alcohol 3a, permite obtener las cetonas correspondientes con excesos enantiom\u00e9ricos superiores al 90%. por lo tanto, resulta un m\u00e9todo excelente para la preparaci\u00f3n de estas cetonas en forma \u00f3pticamente activa.  2,- la protonaci\u00f3n enantioselectiva sobreestequiom\u00e9trica interna de enolatos de morfolinonas con el 1,2-sulfinil alcohol 3a tiene lugar con una estereoselecci\u00f3n moderada. Tanto las variaciones en el tipo de protonador quiral empleado como el empleado como el empleo de otros procedimientos deprotonaci\u00f3n enantioselectiva (externa y m\u00e9todo ipr) no comportaron mejoras en la estereoselecci\u00f3n obtenida.  3,- la acilaci\u00f3n enzim\u00e1tica se aplica con \u00e9xito a la separaci\u00f3n de la mezcla diastereoisom\u00e9rica de 1,2-sulfinil alcoho<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la protonaci\u00f3n enantioselectiva de enolatos en condiciones catal\u00edticas y estequiom\u00e9tricas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la protonaci\u00f3n enantioselectiva de enolatos en condiciones catal\u00edticas y estequiom\u00e9tricas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gil Tom\u00e1s Jes\u00fas Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gregorio Asensio Aguilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Font cierco <\/li>\n<li>Jaime Primo millo (vocal)<\/li>\n<li>Fernando Aznar gomez (vocal)<\/li>\n<li>pedro Merino filella (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gil Tom\u00e1s Jes\u00fas Javier Objetivos cap\u00edtulo 1 1,- preparaci\u00f3n de 1,2-sulfinil alcoholes quirales mediante una secuencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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