{"id":22049,"date":"2018-03-09T09:12:04","date_gmt":"2018-03-09T09:12:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-sistema-cannabinoide-endogeno-en-enfermedades-neurodegenerativas-extrapiramidales\/"},"modified":"2018-03-09T09:12:04","modified_gmt":"2018-03-09T09:12:04","slug":"implicacion-del-sistema-cannabinoide-endogeno-en-enfermedades-neurodegenerativas-extrapiramidales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-sistema-cannabinoide-endogeno-en-enfermedades-neurodegenerativas-extrapiramidales\/","title":{"rendered":"Implicaci\u00f3n del sistema cannabinoide end\u00f3geno en enfermedades neurodegenerativas extrapiramidales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Lastres Becker <\/strong><\/h2>\n<p>Esta tesis doctoral se ha centrado en el estudio de la implicaci\u00f3n del sistema cannabionoide end\u00f3geno en dos enfermedades neurodegenerativas que afectan al movimiento, la enfermedad de huntington y la enfermedad de parkinson.  para ello, en un primer lugar se ha analizado el estado del sistema endocannabionoide en humanos y modelos animales de estas enfermedades. En la enfermedad de huntington se ha observado un descenso de actividad endocannabinoide en los ganglios basales, tanto al nivel del receptor como de los ligandos end\u00f3genos. Al contrario que en esta enfermedad, en la enfermedad de parkinson, existe un aumento de la actividad endocannabinoide, en especial al nivel de los receptores.  el an\u00e1lisis del estado de este sistema, sirvi\u00f3 de base para el dise\u00f1o de estrategias farmacol\u00f3gicas frente a la sintomatolog\u00eda de la enfermedad de huntington.  los resultados que se obtuvieron al respecto muestran que los compuestos con mayor eficacia frente a la hiperactividad caracter\u00edstica de esta enfermedad, son los que se unen tanto al receptor cannabionoide como al receptor vanilloides.  los receptores vanilloides se encuentran en las mismas \u00e1reas cerebrales que el receptor cb1, y parece que estos dos sistemas est\u00e1n \u00edntimamente relacionados al nivel de los ganglios basales. Debido a que estudios previos han observado un efecto neuroprotector de los cannabionoides en distintos modelos degenerativos, nos planteamos analizar dicho efecto en las dos enfermedades. Para ello, realizamos un tratamiento con *9-tetrahidrocannabinol.  este compuesto parece retrasar o enlentecer las lesiones que se producen tanto en la enfermedad de huntington como en la enfermedad de parkinson. pero parece ser, que este efecto no es mediado por el receptor cb1, pudiendo estar implicado el car\u00e1cter antioxidativo de esta mol\u00e9cula. Para finalizar esta tesis doctoral, nos planteamos estudiar el papel de la activaci\u00f3n glial en la neurodegeneraci\u00f3n, y la imp<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n del sistema cannabinoide end\u00f3geno en enfermedades neurodegenerativas extrapiramidales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n del sistema cannabinoide end\u00f3geno en enfermedades neurodegenerativas extrapiramidales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Lastres Becker <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Ramos Atance<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benjam\u00edn Fern\u00e1ndez ruiz <\/li>\n<li>raphael Mechoulan (vocal)<\/li>\n<li>enmanuel Brouillet (vocal)<\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Lastres Becker Esta tesis doctoral se ha centrado en el estudio de la implicaci\u00f3n del sistema [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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