{"id":22083,"date":"2018-03-09T09:12:07","date_gmt":"2018-03-09T09:12:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-polimorfismo-genetico-en-la-apolipoproteina-e-y-c-iii-sobre-la-prevalencia-de-arteriosclerosis-y-demencia-en-la-enfermedad-de-parkinson-con-y-sin-lesiones-vasculares\/"},"modified":"2018-03-09T09:12:07","modified_gmt":"2018-03-09T09:12:07","slug":"influencia-del-polimorfismo-genetico-en-la-apolipoproteina-e-y-c-iii-sobre-la-prevalencia-de-arteriosclerosis-y-demencia-en-la-enfermedad-de-parkinson-con-y-sin-lesiones-vasculares","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/influencia-del-polimorfismo-genetico-en-la-apolipoproteina-e-y-c-iii-sobre-la-prevalencia-de-arteriosclerosis-y-demencia-en-la-enfermedad-de-parkinson-con-y-sin-lesiones-vasculares\/","title":{"rendered":"Influencia del polimorfismo gen\u00e9tico en la apolipoproteina e y c-iii sobre la preValencia de arteriosclerosis y demencia en la enfermedad de parkinson con y sin lesiones vasculares"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andr\u00e9s Jimenez Mar\u00edn <\/strong><\/h2>\n<p>Introducci\u00f3n  la enfermedad de parkinson (ep) est\u00e1 causada por un d\u00e9ficit de dopamina en los ganglios basales. Existe una entidad cl\u00ednica que cursa con los mismos signos y s\u00edntomas que la ep cuyo origen es una lesi\u00f3n vascular en los ganglios basales, llam\u00e1ndose a esta entidad parkinson vascular (pv). Variso estudios han demostrado que la presencia del alelo e4 de la apolipoprote\u00edan e (apo e) comporta un mayor riesgo cardiovascular dado que presenta un peor perfil lip\u00eddico. Asimismo se ha podido comprobar que la posesi\u00f3n de este alelo se asocia con la aparici\u00f3n de la enfermedad de alzheimer (ea) y con la demencia en general. Por otra parte, la presencia del alelo s2 de la apolipoprote\u00edan c-iii (apo c-iii) se ha asociado tambi\u00e9n con un mayor riesgo cardiovascular por presentar un peor perfil lip\u00eddico y unas cifras de tensi\u00f3n arterial m\u00e1s elevadas que los portadores del alelo s1.  objetivos  determinar la frecuencia de los distintos alelos de la apo e y c-iii en la ep y su relaci\u00f3n con los distintos factores de riesgo cardiovascular.  sujetos  209 pacientes diagnosticados de enfermedad de parkinson y\/o temblor, de los cuales 21 hab\u00edan fallecido, 57 no quisieron participar y 43 quedaron excluidos por falta de criterios, quedando un tama\u00f1o muestral final de 88 pacientes, de los cuales 53 casos (60%) correspondieron a hombres y 35 (40%) a mujeres.  m\u00e9todos  se realiz\u00f3 a todos los pacientes una exploraci\u00f3n f\u00edsica. Para determinar la presencia de lesiones vasculares cerebrales se practic\u00f3 una resonancia magn\u00e9tica cerebral (rm-c). Se comprob\u00f3 el grado de deterioro cognitivo por medio del test mental de folste\u00edn. Se procedi\u00f3 a la determinaci\u00f3n del polimorfismo gen\u00e9tico de la apolipoprote\u00edna e y c-iii para valorar las distintas frecuencias al\u00e9licas.  dise\u00f1o  estudio descriptivo transversal.  resultados  el 27% de los pacientes presentaron lesiones vasculares en ganglios basales en la rm-c. El 26% de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del polimorfismo gen\u00e9tico en la apolipoproteina e y c-iii sobre la preValencia de arteriosclerosis y demencia en la enfermedad de parkinson con y sin lesiones vasculares<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del polimorfismo gen\u00e9tico en la apolipoproteina e y c-iii sobre la preValencia de arteriosclerosis y demencia en la enfermedad de parkinson con y sin lesiones vasculares <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andr\u00e9s Jimenez Mar\u00edn <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Espino Montoro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li> L\u00f3pez chozas Jos\u00e9 Manuel (vocal)<\/li>\n<li>Antonio Toledo farr\u00e9 (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Jimenez Mar\u00edn Introducci\u00f3n la enfermedad de parkinson (ep) est\u00e1 causada por un d\u00e9ficit de dopamina en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[66217,2095,66218,49288,1935],"class_list":["post-22083","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-andres-jimenez-marin","tag-antonio-espino-montoro","tag-antonio-toledo-farre","tag-lopez-chozas-jose-manuel","tag-pedro-sanchez-guijo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22083","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22083"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22083\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22083"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22083"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}