{"id":22105,"date":"2018-03-09T09:12:09","date_gmt":"2018-03-09T09:12:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-factor-nuclear-nf-kb-en-modelos-de-inflamacion-neutrofa%c2%adlica-y-eosinofilica-experimentales-y-su-modificacion-mediante-herramientas-farmacologicas-de-caracter-antioxidante\/"},"modified":"2018-03-09T09:12:09","modified_gmt":"2018-03-09T09:12:09","slug":"implicacion-del-factor-nuclear-nf-kb-en-modelos-de-inflamacion-neutrofa%c2%adlica-y-eosinofilica-experimentales-y-su-modificacion-mediante-herramientas-farmacologicas-de-caracter-antioxidante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-factor-nuclear-nf-kb-en-modelos-de-inflamacion-neutrofa%c2%adlica-y-eosinofilica-experimentales-y-su-modificacion-mediante-herramientas-farmacologicas-de-caracter-antioxidante\/","title":{"rendered":"Implicaci\u00f3n del factor nuclear nf-kb en modelos de inflamaci\u00f3n neutrof\u00edlica y eosinofilica experimentales y su modificaci\u00f3n mediante herramientas farmacol\u00f3gicas de car\u00e1cter antioxidante"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sebasti\u00e1n Blesa Luj\u00e1n <\/strong><\/h2>\n<p>Estudio de la modulaci\u00f3n del factor nuclear nk-kb mediante el uso de f\u00e1rmacos antioxidantes n-acetil cystelina en modelos murinos de asma al\u00e9rgica y fibrosis pulmonar inducida por bleomicina. Puesto que ambas patolog\u00edas presentan una importante base inflamatoria en su inicio y desarrollo, y se ha relacionado directamente los fen\u00f3menos de stress oxidativo en las v\u00edas a\u00e9reas con la inflamaci\u00f3n, se ha realizado un estudio del efecto de la ingesta oral de n-acetil cystelina sobre una serie de par\u00e1metros directamente relacionados con la respuesta inflamatoria y la defensa antioxidante.  de este modo se realiz\u00f3, para ambos modelos un estudio de la activaci\u00f3n de nk-kb, la activaci\u00f3n de la inducci\u00f3n del enzima implicado inos (implicado directamente en la patolog\u00eda inflamatoria de las v\u00edas \u00e1reas por generar no) y de la inmunolog\u00eda icam (implicada tambi\u00e9n en este tipo de patolog\u00eda), as\u00ed como par\u00e1metros cl\u00e1sicos de ambas patolog\u00edas.  de este modo, se ha constatado que el tratamiento oral con nac produce la activaci\u00f3n de los par\u00e1metros moleculares en ambos modelos. Finalmente se aportan tambi\u00e9n evidencias sobre la posible modulaci\u00f3n a trav\u00e9s de p38mapk de la actividad de nf-kb en el modelo de fibrosis pulmonar inducida por bleomicina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n del factor nuclear nf-kb en modelos de inflamaci\u00f3n neutrof\u00edlica y eosinofilica experimentales y su modificaci\u00f3n mediante herramientas farmacol\u00f3gicas de car\u00e1cter antioxidante<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n del factor nuclear nf-kb en modelos de inflamaci\u00f3n neutrof\u00edlica y eosinofilica experimentales y su modificaci\u00f3n mediante herramientas farmacol\u00f3gicas de car\u00e1cter antioxidante <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sebasti\u00e1n Blesa Luj\u00e1n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio Cortijo Gimeno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: federico Pallard\u00f3 calatayud <\/li>\n<li>pablo vicente Escrib\u00e1 ruiz (vocal)<\/li>\n<li>j. oriol Bulbena moreu (vocal)<\/li>\n<li>guillermo Saez tormo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sebasti\u00e1n Blesa Luj\u00e1n Estudio de la modulaci\u00f3n del factor nuclear nk-kb mediante el uso de f\u00e1rmacos antioxidantes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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