{"id":22125,"date":"2018-03-09T09:12:11","date_gmt":"2018-03-09T09:12:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-iminoazucares-a-partir-de-eteres-de-bislactima-y-derivados-de-treosa-ribosa-y-eritrosa\/"},"modified":"2018-03-09T09:12:11","modified_gmt":"2018-03-09T09:12:11","slug":"sa%c2%adntesis-de-iminoazucares-a-partir-de-eteres-de-bislactima-y-derivados-de-treosa-ribosa-y-eritrosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/a-coruna\/sa%c2%adntesis-de-iminoazucares-a-partir-de-eteres-de-bislactima-y-derivados-de-treosa-ribosa-y-eritrosa\/","title":{"rendered":"S\u00edntesis de iminoaz\u00facares a partir de \u00e9teres de bislactima y derivados de treosa, ribosa y eritrosa"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Ruanova Su\u00e1rez Tania M. <\/strong><\/h2>\n<p>En este trabajo de tesis doctoral se ha desarrollado una nueva metodolog\u00eda para la s\u00edntesis convergente de iminoaz\u00facares, an\u00e1logos de los az\u00facares en donde el \u00e1tomo de ox\u00edgeno del anillo se reemplaza por un \u00e1tomo de nitr\u00f3geno. los imioaz\u00facares son mol\u00e9culas de gran importancia biol\u00f3gica, pues act\u00faan como potentes inhibores de glicosidadas y glicosiltransferasas y, por ello, pueden ser de utilidad en el desarrollo de nuevos agentes terap\u00e9uticos para el diagn\u00f3stico y el tratamiento de enfermedades relacionadas con el reconocimiento y el procesado de carbohidratos.  la estrategia elegida para la s\u00edntesis de iminoaz\u00facares se fundamenta en la desconexi\u00f3n del ciclo a trav\u00e9s de los enlaces n-c(omega) y c(alfa)-c(beta), lo  que permite la elecci\u00f3n de la glicina y diversos polihidroxialdeh\u00eddos como materiales de partida. Para la construcci\u00f3n estereoselectiva de los polihidroxiamino\u00e1cidos, que constituyen los intermedios sint\u00e9ticos clave, se plante\u00f3 la utilizaci\u00f3n de reacciones ald\u00f3licas de \u00e9teres de bislactima derivados de la glicina y la valina y 1,3-dioxolano-4-carbaldeh\u00eddos con tendencias diastereofaciales complementarias y no complementarias, atendiendo a la combinaci\u00f3n de los modelos de zimmerman-traxler y felkin-anh.  se ha comprobado que las reacciones de adici\u00f3n de azaenolatos derivados de \u00e9teres de bislactima de contrai\u00f3n met\u00e1lico sobre los 1, 3-dioxolano-4-carbaldeh\u00eddos derivados de la treosa, ribosa y eritrosa transcurren de manera eficiente a baja temperatura, y permiten la obtenci\u00f3n selectiva de aductos de configuraci\u00f3n (trans, sin, anti), (trans, anti, anti) y (trans, sin, sin) en buenos rendimientos.  el curso estereoqu\u00edmico de estas adiciones de tipo ald\u00f3lica puede racionalizarse asumiendo un control cin\u00e9tico del proceso y la participaci\u00f3n de estados de transici\u00f3n c\u00edclicos, que de acuerdo con los resultados del c\u00e1lculo deben ser de seis miembros y tipo silla en las adiciones sobre alde<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de iminoaz\u00facares a partir de \u00e9teres de bislactima y derivados de treosa, ribosa y eritrosa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de iminoaz\u00facares a partir de \u00e9teres de bislactima y derivados de treosa, ribosa y eritrosa <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Ruanova Su\u00e1rez Tania M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>romero Ruiz Pita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Yus astiz <\/li>\n<li>esther Dominguez perez (vocal)<\/li>\n<li>Jos\u00e9 Fuentes mota (vocal)<\/li>\n<li>carmen N\u00e1jera domingo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruanova Su\u00e1rez Tania M. En este trabajo de tesis doctoral se ha desarrollado una nueva metodolog\u00eda para [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[18576],"tags":[19243,21276,10975,5623,66323,66322],"class_list":["post-22125","post","type-post","status-publish","format-standard","hentry","category-a-coruna","tag-carmen-najera-domingo","tag-esther-dominguez-perez","tag-jose-fuentes-mota","tag-miguel-angel-yus-astiz","tag-romero-ruiz-pita","tag-ruanova-suarez-tania-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22125"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22125\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}