{"id":2213,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/estudio-comparado-de-la-cinetica-de-distribucion-de-ofloxacino-y-ciprofloxacino\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"estudio-comparado-de-la-cinetica-de-distribucion-de-ofloxacino-y-ciprofloxacino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-comparado-de-la-cinetica-de-distribucion-de-ofloxacino-y-ciprofloxacino\/","title":{"rendered":"Estudio comparado de la cinetica de distribucion de ofloxacino y ciprofloxacino"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Colino Gandarillas Clara Isabel <\/strong><\/h2>\n<p>Se ha realizado un estudio comparativo de la cinetica de distribucion de ofloxacino y ciprofloxacino a eritrocitos \u00abin vitro\u00bb e \u00abin vivo\u00bb, en conejos, asi como el estudio de su distribucion tisular realizado tambien en conejos.  el analisis de los datos \u00abin vitro\u00bb se realizao mediante tres modelos de fijacion: lineal, no lineal y mixto. Para los datos \u00abin vivo\u00bb de eritrocitos se usaron dos modelos:  uno especifico de distribucion de caracter compartimental y otro seufisiologico. Tambien se utilizaron metodos modelo independiente como los momentos estadisticos, calculandose los tiempos medios de residencia y tiempos medios de transito y la deconvolucion numerica, que permitio estimar la cinetica de incorporacion a los eritrocitos. Ambas quinolonas penetran bien en los eritrocitos siguiendo un modelo de distribucion limitado por el flujo.  para el estudio de la distribucion tisular se calcularon los coeficientes de reparto en diversos tejidos del conejo. Se utilizo tambien un modelo fisiologico limitado por el flujo que permitio simular la evolucion de los niveles en los tejidos y estimar los errores de prediccion que fueron siempre menores al 10%.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio comparado de la cinetica de distribucion de ofloxacino y ciprofloxacino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio comparado de la cinetica de distribucion de ofloxacino y ciprofloxacino <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Colino Gandarillas Clara Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amparo Sanchez Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfonso Jes\u00fas Dominguez Gil Hurle <\/li>\n<li>Isabel Gonzalez Alonso (vocal)<\/li>\n<li>Julio Moratinos Areces (vocal)<\/li>\n<li>Pilar Pastoriza Abad (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Colino Gandarillas Clara Isabel Se ha realizado un estudio comparativo de la cinetica de distribucion de ofloxacino [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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