{"id":22151,"date":"2018-03-09T09:12:12","date_gmt":"2018-03-09T09:12:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senalizacion-de-la-insulina-en-adipocitos-marrones-carentes-del-receptor-de-igf-i\/"},"modified":"2018-03-09T09:12:12","modified_gmt":"2018-03-09T09:12:12","slug":"senalizacion-de-la-insulina-en-adipocitos-marrones-carentes-del-receptor-de-igf-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senalizacion-de-la-insulina-en-adipocitos-marrones-carentes-del-receptor-de-igf-i\/","title":{"rendered":"Se\u00f1alizaci\u00f3n de la insulina en adipocitos marrones carentes del receptor de igf-i"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cecilia Mur P\u00e9rez <\/strong><\/h2>\n<p>La insulina y el igf-i son dos se\u00f1ales biol\u00f3gicas implicadas en proliferaci\u00f3n, diferenciaci\u00f3n y supervivencia. Para llevar a cabo sus acciones deben interaccionar con los receptores de membrana espec\u00edficos que pertenecen a la familia de los receptores tirosina quinasa. La uni\u00f3n del lignado a su receptor pone en marcha una cascada de fosforilaciones que activa dos v\u00edas fundamentales: la ruta de la pi3-quinasa y la ruta de las mapk. Si bien las acciones finales de igf-i e insulina no son las mismas, hasta el momento no se han detectado diferencias sustanciales en la cascada de transducci\u00f3n de se\u00f1ales entre ambas mol\u00e9cular. Los adipocitos marrones presentan de forma fisiol\u00f3gica un elevado n\u00famero de receptores tanto de igf-i como de insulina. La falta del receptor de igf-i en los adipocitos marrones durante el desarrollo origina cambios profundos en dichas c\u00e9lulas, produci\u00e9ndose una alteraci\u00f3n en la ruta de transducci\u00f3n de se\u00f1ales de la insulina.  los adipocitos marrones experimentan un aumento de la sensibilidad a la insulina, que se traduce en la mayor estimulaci\u00f3n de la cascada de las mapk y de la pi-3 quinasa.  el origen de esta ganancia de funci\u00f3n parece encontrarse en la p\u00e9rdida de actividad de la fosfatasa ptp1b, encargada en las c\u00e9lulas salvajes de la defosforilaci\u00f3n del receptor de insulina y del irs-1.  como consecuencia se produce una mayor respuesta proliferativa de la insulina de los adipocitos marrones sin receptor de igf-i.  sin embargo, la sobreactivaci\u00f3n de la cascada de la pi3k\/akt no es suficiente para compensar la falta del receptor de igf-i en la diferenciaci\u00f3n de los adipocitos marrones.  en estas c\u00e9lulas la insulina no es capaz de inducir adecuadamente los factores de transcripci\u00f3n involucrados en diferenciaci\u00f3n adipog\u00e9nica y termog\u00e9nica.  otros par\u00e1metros metab\u00f3licos como la incorporaci\u00f3n de glucosa al interior celular no se encuentran alterados. Por otra parte, la falta de receptor<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Se\u00f1alizaci\u00f3n de la insulina en adipocitos marrones carentes del receptor de igf-i<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Se\u00f1alizaci\u00f3n de la insulina en adipocitos marrones carentes del receptor de igf-i <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cecilia Mur P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Roman Benito De Las Heras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  teresa Miras portugal <\/li>\n<li>Luis Goya suarez (vocal)<\/li>\n<li>Juan  Emilio Feliu albi\u00f1ana (vocal)<\/li>\n<li>jane Burks deborah (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cecilia Mur P\u00e9rez La insulina y el igf-i son dos se\u00f1ales biol\u00f3gicas implicadas en proliferaci\u00f3n, diferenciaci\u00f3n y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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