{"id":22155,"date":"2018-03-09T09:12:13","date_gmt":"2018-03-09T09:12:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/endocarditis-infecciosa-experimental-por-enterococcus-faecalis-altamente-resistente-a-aminoglucosidos\/"},"modified":"2018-03-09T09:12:13","modified_gmt":"2018-03-09T09:12:13","slug":"endocarditis-infecciosa-experimental-por-enterococcus-faecalis-altamente-resistente-a-aminoglucosidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/murcia\/endocarditis-infecciosa-experimental-por-enterococcus-faecalis-altamente-resistente-a-aminoglucosidos\/","title":{"rendered":"Endocarditis infecciosa experimental por enterococcus faecalis altamente resistente a aminoglucosidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diego Roldan Conesa <\/strong><\/h2>\n<p>Antecedentes y objetivos  recientemente se ha observado un aumento de infecciones debidas a enterococcus faecalis altamente resistente a aminogluc\u00f3sidos. Con el objeto de comparar la eficacia de teicoplanina en monoterapia o asociada a otros antibi\u00f3ticos, y nuevas propuestas de tratamiento; valoramos la eficacia de estos antibi\u00f3ticos en un modelo experimental de endocarditis en conejo.  material y m\u00e9todos  realizamos un ensayo con 84 conejos a los que se les induce endocarditis a\u00f3rtica, mediante la introducci\u00f3n de un cat\u00e9ter v\u00eda arteria car\u00f3tida derecha; 24 horas tras la inserci\u00f3n del cat\u00e9ter, cada conejo se inocula con 108 ufc\/ml de enterococcus faecalis v\u00eda vena marginal de la oreja. Se inicia tratamiento 48 horas despu\u00e9s de la inoculaci\u00f3n bacteriana. Los conejos fueron tratados durante 5 d\u00edas. Doce o veinticuatro horas despu\u00e9s de la \u00faltima dosis, seg\u00fan pauta, los conejos fueron sacrificados. Las vegetaciones de cada animal fueron cultivadas cuantitativamente. Se utilizaron 14 conejos como grupo control, sin tratamiento antibi\u00f3tico, 14 conejos se trataron con teicoplanina 20 mg\/kg\/12 h intramuscular (im); 12 con teicoplanina + ceftriaxona 30 mg\/kg\/12 h (im); 18 con teicoplanina + levofloxacino 30 mg\/kg\/12 h (im); 12 con teicoplanina + imipenen 60 mg\/kg\/8 h (im); y 14 con ampiciclina 100 mg\/kg\/8 h + ceftriaxona.  resultados  la media de los logaritmos en base 10 (log 10) de las unidades formadoras de colonias por gramo (ufc\/g) de vegetaci\u00f3n fue: grupo control 9,88  0,52 log10 ufc7g; teicoplanina 7,47  0,38 log10 ufc\/g; teicoplanina + ceftriaxona 6,82  0,78 ufc\/g; teicoplanina + levofloxacino 7,47  0,77 ufc\/g; teicoplanina + imipenen 5,43  0,68 ufc\/g ampicilina + ceftriaxona 7,48  0,70 ufc\/g.  conclusiones  hemos encontrado eficacia en el tratamiento de todos los grupos respecto al control en la reducci\u00f3n de la concentraci\u00f3n del enterococcus faecalis en las vegetaciones a\u00f3rticas (p&lt;0,001). El tratamiento<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Endocarditis infecciosa experimental por enterococcus faecalis altamente resistente a aminoglucosidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Endocarditis infecciosa experimental por enterococcus faecalis altamente resistente a aminoglucosidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diego Roldan Conesa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda no Valdes Chavarri<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino sanchez <\/li>\n<li>Manuel Segovia hern\u00e1ndez (vocal)<\/li>\n<li>Juan Custardoy olabarrieta (vocal)<\/li>\n<li>federico Soria arcos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diego Roldan Conesa Antecedentes y objetivos recientemente se ha observado un aumento de infecciones debidas a enterococcus [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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