{"id":22194,"date":"2018-03-09T09:12:16","date_gmt":"2018-03-09T09:12:16","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-genica-diferencial-y-regulacion-de-ferritina-en-un-modelo-animal-de-enfermedad-de-parkinson\/"},"modified":"2018-03-09T09:12:16","modified_gmt":"2018-03-09T09:12:16","slug":"expresion-genica-diferencial-y-regulacion-de-ferritina-en-un-modelo-animal-de-enfermedad-de-parkinson","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/expresion-genica-diferencial-y-regulacion-de-ferritina-en-un-modelo-animal-de-enfermedad-de-parkinson\/","title":{"rendered":"Expresi\u00f3n g\u00e9nica diferencial y regulaci\u00f3n de ferritina en un modelo animal de enfermedad de parkinson"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Mar Cuadrado Tejedor <\/strong><\/h2>\n<p>En la enfermedad de parkinson (ep), se produce una p\u00e9rdida de las neuronas dopamin\u00e9rgicas a nivel de la sustancia negra, que provoca una depleci\u00f3n de la dopamina estriatal. En el estriado, la uni\u00f3n de la dopomina a su receptor activa cascadas de se\u00f1alizaci\u00f3n al n\u00facleo que regulan la expresi\u00f3n de ciertos genes.  mediante el empleo de la t\u00e9cnica de differential display, hemos analizado posibles alteraciones en la expresi\u00f3n g\u00e9nica estriatal, en dos modelos animales de ep obtenidos mediante la administraci\u00f3n de la neurotoxina mptp. hemos encontrado alteraci\u00f3n en la expresi\u00f3n de genes del genoma mitocondrial y de la familia del citosqueleto celular (radixina, cofilina y centractina).  asimismo, como en la ep se ha descrito un aumento del contenido de hierro, hemos analizado en los mismos modelos animales de ep, la expreis\u00f3n de ferritina, prote\u00edna que participa en su almancenamiento. Los niveles de ferritina, disminuyen en el estriado de ambos modelos animales. El estudio \u00abin vitro\u00bb de la regulaci\u00f3n de ferritina, muestra como la dopamina a trav\u00e9s de la uni\u00f3n a su receptor d1, aumenta los niveles de su mensajero, y que, por un mecanismo de sus receptores, act\u00faa como agente quelante de hierro. De este modo, la depleci\u00f3n de la dopamina estriatal en los modelos animales de ep, podr\u00eda ser la responsable de la disminuci\u00f3n de ferritina que observamos en el estriado de los animales mptp.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n g\u00e9nica diferencial y regulaci\u00f3n de ferritina en un modelo animal de enfermedad de parkinson<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n g\u00e9nica diferencial y regulaci\u00f3n de ferritina en un modelo animal de enfermedad de parkinson <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Mar Cuadrado Tejedor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lourdes Ortiz Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Gimenez amaya <\/li>\n<li>jordi Perez tur (vocal)<\/li>\n<li> L\u00f3pez de munain adolfo (vocal)<\/li>\n<li>Francisco Javier S\u00e1ez castresana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Mar Cuadrado Tejedor En la enfermedad de parkinson (ep), se produce una p\u00e9rdida de las neuronas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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