{"id":22284,"date":"2018-03-09T09:12:23","date_gmt":"2018-03-09T09:12:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-vascular-del-vegf-y-de-sus-receptores-en-la-hipercolesterolemia-experimental-y-su-modulacion-por-la-atorvastatina\/"},"modified":"2018-03-09T09:12:23","modified_gmt":"2018-03-09T09:12:23","slug":"analisis-de-la-expresion-vascular-del-vegf-y-de-sus-receptores-en-la-hipercolesterolemia-experimental-y-su-modulacion-por-la-atorvastatina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/analisis-de-la-expresion-vascular-del-vegf-y-de-sus-receptores-en-la-hipercolesterolemia-experimental-y-su-modulacion-por-la-atorvastatina\/","title":{"rendered":"An\u00e1lisis de la expresi\u00f3n vascular del vegf y de sus receptores en la hipercolesterolemia experimental y su modulaci\u00f3n por la atorvastatina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Maitane P\u00e9rez-iizarbe Saragueta <\/strong><\/h2>\n<p>El factor de crecimiento del endotelio vascular (vegf), a trav\u00e9s de sus receptores vegfr-1 y vegfr-2, presenta un doble papel en la homeostasis vascular: adem\u00e1s de ser el principal responsable de la angiog\u00e9nesis, controlar la permeabilidad vascular y participar en el mantenimiento de la integridad endotelial, tambi\u00e9n puede favorecer el desarrollo de la placa ateroscler\u00f3tica. el objetivo de este estudio fue determinar si la expresi\u00f3n de este factor de crecimiento y sus receptores estaban aumentada en un modelo de hipercolesterolemia experimental y si el tratamiento con atorvastatina podr\u00eda reducirla. Para ello se utilizaron ratones apoe deficientes (apoe -\/-) de 3 meses, sin aterosclerosis establecidad, y de 6 meses, que presentaban lesiones ateroscler\u00f3ticas macrosc\u00f3picamente visibles.  los ratones apoe -\/- pre-ateroscler\u00f3ticos, adem\u00e1s de un elevado estr\u00e9s oxidativo, mostraron una mayor expresi\u00f3n a\u00f3rtica y cardiaca del vegf y vegfr-2 que los ratones normales. Asimismo, se observ\u00f3 un aumento en la expresi\u00f3n del arnm del vegfr-1 cardiaco. El tratamiento con atorvastatina, que redujo la peroxidaci\u00f3n lip\u00eddica, disminuy\u00f3 la expresi\u00f3n a\u00f3rtica y cardica del vegf y vegfr-2, as\u00ed como la expresi\u00f3n cardiaca del vegfr-1. En los ratones apoe -\/- ateroscler\u00f3ticos se observ\u00f3 que el tratamiento con atorvastatina provoc\u00f3 una reducci\u00f3n de la extensi\u00f3n de las lesiones ateroscler\u00f3ticas y de la expresi\u00f3n del vegf de las mismas.  la sobreexpresi\u00f3n vascular del vegf y su receptores en la hipercolesterolemia puede constituir un elemento relevante en el inicio y progresi\u00f3n de la aterosclerosis, y la reducci\u00f3n de su expresi\u00f3n podr\u00eda constituir una estrategia terap\u00e9utica en el prevenci\u00f3n del desarrollo de esta patolog\u00eda. Este mecanismos podr\u00eda contribuir a explicar los efectos beneficiosos de la  atorvastatina en el tratamiento de la aterosclerosis, tanto la prevenci\u00f3n del desarrollo de la lesi\u00f3n como la estabilizaci\u00f3n de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la expresi\u00f3n vascular del vegf y de sus receptores en la hipercolesterolemia experimental y su modulaci\u00f3n por la atorvastatina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la expresi\u00f3n vascular del vegf y de sus receptores en la hipercolesterolemia experimental y su modulaci\u00f3n por la atorvastatina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Maitane P\u00e9rez-iizarbe Saragueta <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodr\u00edguez Garc\u00eda Jos\u00e9 Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lLuis Masana mart\u00edn <\/li>\n<li>Fernando Civeira murillo (vocal)<\/li>\n<li>Jes\u00fas De la osada Garc\u00eda (vocal)<\/li>\n<li>Mar\u00eda mercedes Garayoa berrueta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Maitane P\u00e9rez-iizarbe Saragueta El factor de crecimiento del endotelio vascular (vegf), a trav\u00e9s de sus receptores vegfr-1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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