{"id":22340,"date":"2018-03-09T09:12:28","date_gmt":"2018-03-09T09:12:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-geneticas-en-las-regiones-18q21-y-3p14-en-el-adenocarcinoma-gastrico-relacion-con-otros-parametros-cla%c2%adnico-morfologicos-y-valor-pronostico\/"},"modified":"2018-03-09T09:12:28","modified_gmt":"2018-03-09T09:12:28","slug":"alteraciones-geneticas-en-las-regiones-18q21-y-3p14-en-el-adenocarcinoma-gastrico-relacion-con-otros-parametros-cla%c2%adnico-morfologicos-y-valor-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/alteraciones-geneticas-en-las-regiones-18q21-y-3p14-en-el-adenocarcinoma-gastrico-relacion-con-otros-parametros-cla%c2%adnico-morfologicos-y-valor-pronostico\/","title":{"rendered":"Alteraciones gen\u00e9ticas en las regiones 18q21 y 3p14 en el adenocarcinoma g\u00e1strico: relaci\u00f3n con otros par\u00e1metros cl\u00ednico-morfol\u00f3gicos y valor pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Riva Onand\u00eda Susana Rosa De La <\/strong><\/h2>\n<p>El c\u00e1ncer g\u00e1strico, es todav\u00eda uno de los tumores m\u00e1s comunes del mundo con una incidencia estimada del 10,2% de todos las neoplasias malignas, aunque tanto su tasa de incidencia como de mortalidad presenta gran variabilidad geogr\u00e1fica.  en su desarrollo se han implicado varios factores entre los que destacan los ambientales como la infecci\u00f3n por h.Pylori, condiciones precursoras y alteraciones moleculares.  el adenocarcinoma g\u00e1strico, seg\u00fan las clasificaci\u00f3n de lauren, se divide en dos tipos histol\u00f3gicos bien definidos que presentan diferencias no solo cl\u00ednicas, morfol\u00f3gicas y pron\u00f3sticas, tambi\u00e9n en su desarrollo, con diferente acumulaci\u00f3n de eventos moleculares. Mientras que el adenocarcinoma g\u00e1strico de tipo intestinal se desarrolla a trav\u00e9s de un proceso \u00abmultipaso\u00bb que se inicia con la gastritis cr\u00f3nica y se continua con gastritis atr\u00f3fica, metaplasia y displasia, el tipo difuso parece prescindir de esta evoluci\u00f3n multipaso. Seh especulado con la posibilidad de que la carcinog\u00e9nesis g\u00e1strica presente una v\u00eda de desarrollo predominante similar a la progresi\u00f3n adenoma-adenocarcinoma colorrectal. Sin embargo esta acumulaci\u00f3n secuencial de alteraciones gen\u00e9ticas que ocurre en los tumores colorrectales no se ha podido probar plentamente en el adenocarcinoma g\u00e1strico.  existen suficientes evidencias y resultados controvertidos sobre la posible implicaci\u00f3n de varios genes supresores de tumor y oncogenes en la carcinog\u00e9nesis g\u00e1strica, con diferentes eventos gen\u00e9ticos y distinto predominio seg\u00fan el tipo histol\u00f3gico de tumor. Puesto que la secuencia de estas alteraciones gen\u00e9ticas en el desarrollo del adenocarcinoma g\u00e1strico no est\u00e1 del todo establecida y puesto que los hallazgos moleculares en los dos tipos histol\u00f3gicos presentan resultados contradictorios, nos propusimos analizar en una serie de 69 pacientes intervenidos en nuestro centro por adenocarcinoma  g\u00e1strico, la incidencia de alteraciones en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones gen\u00e9ticas en las regiones 18q21 y 3p14 en el adenocarcinoma g\u00e1strico: relaci\u00f3n con otros par\u00e1metros cl\u00ednico-morfol\u00f3gicos y valor pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones gen\u00e9ticas en las regiones 18q21 y 3p14 en el adenocarcinoma g\u00e1strico: relaci\u00f3n con otros par\u00e1metros cl\u00ednico-morfol\u00f3gicos y valor pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Riva Onand\u00eda Susana Rosa De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Javier Sola Gallego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Solis erruzo Jos\u00e9 a. <\/li>\n<li>Juan  Antonio Amiguet Garc\u00eda (vocal)<\/li>\n<li>ricardo Sainz samitier (vocal)<\/li>\n<li>Francisco Javier S\u00e1ez castresana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Riva Onand\u00eda Susana Rosa De La El c\u00e1ncer g\u00e1strico, es todav\u00eda uno de los tumores m\u00e1s comunes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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