{"id":22345,"date":"2018-03-09T09:12:28","date_gmt":"2018-03-09T09:12:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-de-la-citogenetica-molecular-al-analisis-genomico-de-las-hemopata%c2%adas-malignas\/"},"modified":"2018-03-09T09:12:28","modified_gmt":"2018-03-09T09:12:28","slug":"aportacion-de-la-citogenetica-molecular-al-analisis-genomico-de-las-hemopata%c2%adas-malignas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/aportacion-de-la-citogenetica-molecular-al-analisis-genomico-de-las-hemopata%c2%adas-malignas\/","title":{"rendered":"Aportaci\u00f3n de la citogen\u00e9tica molecular al an\u00e1lisis gen\u00f3mico de las hemopat\u00edas malignas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gonz\u00e1lez S\u00e1nchez M. Belen <\/strong><\/h2>\n<p>Un elevado porcentaje de los pacientes con leucemias y linfomas tiene cariotipos alterados. Gran parte de esos cambios cromos\u00f3micos son recurrentes y se han asociado a tipos morfol\u00f3gicos espec\u00edficos tanto de estirpe mieloide como linfoide. La citogen\u00e9tica juega un papel importante en el diagn\u00f3stico y constituye, adem\u00e1s, un indicador pron\u00f3stico independiente; pero necesita del apoyo de metodolog\u00edas complementarias, como las t\u00e9cnicas de citogen\u00e9tica molecular que tienen alta sensibilidad y especificidad.  mediante la aplicaci\u00f3n de t\u00e9cnicas de citogen\u00e9tica molecular basadas en la hisf y tomando como referencia la citogen\u00e9tica convencional, se abordaron los siguientes estudios:  1,- dise\u00f1o de un m\u00e9todo sencillo y eficaz para la detecci\u00f3n de reordenamientos del cromosoma 16, caracter\u00edsticos de la lam-m4eo. Se demuestra que la hisf aporta m\u00e1s informaci\u00f3n que la citogen\u00e9tica convencional y es equiparable a los estudios moleculares (rt-pcr), por lo que debe incorporarse al estudio sistem\u00e1tico de estos enfermos.  2,- estudio de la regi\u00f3n 7q31-q34 en pacientes con hemopat\u00edas mieloides y alteraciones del 7q por citogen\u00e9tica convencional. La gran heterogeneidad encontrada en el estudio sugiere la participaci\u00f3n de diferentes mecanismos en la patog\u00e9nesis de la enfermedad. Las aberraciones de 7q representar\u00edan fen\u00f3menos secundarios en la progresi\u00f3n tumoral, lo que justificar\u00eda el mal pron\u00f3stico que tienen estos enfermos.  3,- an\u00e1lisis de las alteraciones g\u00e9nicas presentes en la t(8;12)(q12;q13) en enfermos con hemopat\u00edas mieloides. Asociada a la translocaci\u00f3n aparece una deleci\u00f3n intersticial que afecta a los genes etv6 y cdkn1b(p27\/kip1). adem\u00e1s se encuentra una amplificaci\u00f3n del gen ccnd2.  4,- caracterizaci\u00f3n de la t(6;14) en pacientes con lezm\/lelv. Se demuestra que ccnd3 est\u00e1 implicado en la g\u00e9nesis de algunos lezm\/lelv, mediante la translocaci\u00f3n con el gen de la cadena pesada de las inmunoglobulinas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportaci\u00f3n de la citogen\u00e9tica molecular al an\u00e1lisis gen\u00f3mico de las hemopat\u00edas malignas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportaci\u00f3n de la citogen\u00e9tica molecular al an\u00e1lisis gen\u00f3mico de las hemopat\u00edas malignas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gonz\u00e1lez S\u00e1nchez M. Belen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/03\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Mar\u00eda Hernandez Rivas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas fernando San Miguel izquierdo <\/li>\n<li>f\u00e9lix Carbonell ram\u00f3n (vocal)<\/li>\n<li>francesc Sole ristol (vocal)<\/li>\n<li>isidro Javier S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonz\u00e1lez S\u00e1nchez M. Belen Un elevado porcentaje de los pacientes con leucemias y linfomas tiene cariotipos alterados. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9386],"tags":[39952,49761,66864,40871,9596,66865],"class_list":["post-22345","post","type-post","status-publish","format-standard","hentry","category-salamanca","tag-felix-carbonell-ramon","tag-francesc-sole-ristol","tag-gonzalez-sanchez-m-belen","tag-isidro-javier-sanchez-garcia","tag-jesus-fernando-san-miguel-izquierdo","tag-jesus-maria-hernandez-rivas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22345"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22345\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}