{"id":22364,"date":"2003-01-04T00:00:00","date_gmt":"2003-01-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-y-regulacion-de-la-expresion-de-los-genes-de-la-familia-hsp83-90-en-leishmania-infantum\/"},"modified":"2003-01-04T00:00:00","modified_gmt":"2003-01-04T00:00:00","slug":"caracterizacion-y-regulacion-de-la-expresion-de-los-genes-de-la-familia-hsp83-90-en-leishmania-infantum","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-y-regulacion-de-la-expresion-de-los-genes-de-la-familia-hsp83-90-en-leishmania-infantum\/","title":{"rendered":"Caracterizaci\u00f3n y regulaci\u00f3n de la expresi\u00f3n de los genes de la familia hsp83\/90 en leishmania infantum"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruth Larreta L\u00f3pez <\/strong><\/h2>\n<p>Leishmania es un protozzo par\u00e1sito perteneciente al orden de los kinetopl\u00e1stidos. su ciclo de vida incluye la alternancia entre dos hospedadores: un hospedador mam\u00edfero y un insecto vector. Las enfermedades producidas por leishmania se denominan lishmaniosis, t\u00e9rmino que engloba a un conjunto de s\u00edndromes de diferente gravedad y manifestaciones cl\u00ednicas. Leishmania tiene un origen evolutivo muy antiguo, por lo que presenta una serie de caracter\u00edsticas moleculares de organizaci\u00f3n y expresi\u00f3n g\u00e9nicas propias.  en esta tesis doctoral se han caracterizado los genes grp94 y hsp83 de leishmania infantum, ambos pertenecientes a la familia de prote\u00ednas de choque t\u00e9rmico hsp83\/90.  la prote\u00edna grp94 de l.Infantum ha resultado ser un ant\u00edgeno prominente en la infecci\u00f3n por el par\u00e1sito, mostr\u00e1ndose como un ant\u00edgeno temprano. el mapeo de ep\u00edtopos inmunodominantes demostr\u00f3 que se localizan en las regiones menos conservadas de la prote\u00edna. Estas caracter\u00edsticas pueden ser potencialmente utilziadas para el desarrollo de un sistema de diagn\u00f3stico serol\u00f3gico para la detecci\u00f3n precoz de la infecci\u00f3n.  la regulaci\u00f3n de la expresi\u00f3n del gen hsp83 durante el choque t\u00e9rmico provoca una acumulaci\u00f3n del rnam del mismo, por un mecanismo que opera a nivel post-transcripcional, en el cual a temperaturas de choque t\u00e9rmico existe un factor proteico de nueva s\u00edntesis que protege a los mensajeros de ser degradados. Adem\u00e1s, esos mensajeros se traducen de manera preferencial.  en el proceso  de diferenciaci\u00f3n de la forma promastigote a la amastigote el gen hsp 83 est\u00e1 fuertemente regulado. Tanto a nivel de rnam como de prote\u00edna de nueva s\u00edntesis de observa una fuerte inducci\u00f3n en los primeros momentos del proceso seguida de una p\u00e9rdida de esa inducci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n y regulaci\u00f3n de la expresi\u00f3n de los genes de la familia hsp83\/90 en leishmania infantum<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n y regulaci\u00f3n de la expresi\u00f3n de los genes de la familia hsp83\/90 en leishmania infantum <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruth Larreta L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Requena Rolan\u00eda Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Cuezva marcos <\/li>\n<li>Manuel Carlos L\u00f3pez l\u00f3pez (vocal)<\/li>\n<li>vicente Larraga rodr\u00edguez de vera (vocal)<\/li>\n<li>Francisco Zafra gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruth Larreta L\u00f3pez Leishmania es un protozzo par\u00e1sito perteneciente al orden de los kinetopl\u00e1stidos. su ciclo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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