{"id":22379,"date":"2003-02-04T00:00:00","date_gmt":"2003-02-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-inmunohistoqua%c2%admica-del-oncogen-ret-ptc-de-los-reguladores-de-la-apoptosis-bcl-2-caspasa-y-p-53-e-indice-de-proliferacion-celular-ki-67-en-tumores-oncociticos\/"},"modified":"2003-02-04T00:00:00","modified_gmt":"2003-02-04T00:00:00","slug":"expresion-inmunohistoqua%c2%admica-del-oncogen-ret-ptc-de-los-reguladores-de-la-apoptosis-bcl-2-caspasa-y-p-53-e-indice-de-proliferacion-celular-ki-67-en-tumores-oncociticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sevilla\/expresion-inmunohistoqua%c2%admica-del-oncogen-ret-ptc-de-los-reguladores-de-la-apoptosis-bcl-2-caspasa-y-p-53-e-indice-de-proliferacion-celular-ki-67-en-tumores-oncociticos\/","title":{"rendered":"Expresi\u00f3n inmunohistoqu\u00edmica del oncogen ret\/ptc, de los reguladores de la apoptosis (bcl-2, caspasa y p-53) e indice de proliferaci\u00f3n celular ki-67 en tumores oncociticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lag Asturiano M. Encarnaci\u00f3n <\/strong><\/h2>\n<p>Las neoplasias oncoc\u00edticas u oxif\u00edlicas se presentan en diversos \u00f3rganos, como gl\u00e1ndula tiroides, paratiroides, ri\u00f1\u00f3n y gl\u00e1ndula salival.  en este trabajo de tesis doctoral se dedici\u00f3 estudiar una serie de tumores oncoc\u00edticos de distintos \u00f3rganos, con el fin de detectar, por m\u00e9todo inmunohistoqu\u00edmico, la posible expresi\u00f3n de la prote\u00edna ret. Para ello se aplicaron los anticuerpos monocional y policional en 6 onocitomas renales, 28 tumores de c\u00e9lulas de h\u00ed\u00bcrthle tiroideos, 3 adenomas oxif\u00edlicos parotiroideos y 29 tumores de warthin parot\u00eddeos.  la inmunorreacci\u00f3n result\u00f3 positiva en el 100% de los casos e implicaba, al menos, el 90% del \u00e1rea tumoral. Fue m\u00e1s intensa para los oncocitomas y tumor de warthin y ligeramente m\u00e1s d\u00e9bil para el adenoma oxif\u00edlico de paratiroides.  esta sobreexpresi\u00f3n de la prote\u00edna ret es l\u00f3gica en tumores de c\u00e9lulas de h\u00ed\u00bcrthle del tiroides, donde est\u00e1 demostrado reordenamiento ret\/ptc. de distinta manera, en los casos de paratiroides, ri\u00f1\u00f3n y par\u00f3tida, se cuestionan estos resultados, pues no est\u00e1 demostrado \u00e9ste reordenamiento. probablemente se trate de una reacci\u00f3n cruzada con una prote\u00edna distinta, pues no hay que olvidar que la c\u00e9lulas oncoc\u00edtica muestra avidez por gran cantidad de anticuerpos.  as\u00edmismo, se cuestiona la relaci\u00f3n causal entre la tiroiditis de hashimoto y el carcinoma papilar de tiroides, pues diferentes trabajos se contradicen sobre si \u00e9sta tiroiditis se asocia a reordenamiento ret\/ptc o no.  actualmente se interpreta el cambio oncoc\u00edtico citopl\u00e1smico como un proceso degenerativo o un fen\u00f3meno de envejecimiento celular.  a trav\u00e9s de este estudio tambi\u00e9n se ha pretendido hacer una aproximaci\u00f3n al mejor conocimiento de la naturaleza de la c\u00e9lula oncoc\u00edtica, valorando su capacidad apopt\u00f3tica, mediante la determinaci\u00f3n inmuohistoqu\u00edmica de prote\u00ednas reguladoras (bcl-2, caspasa-3).  la inmunorreacci\u00f3n result\u00f3 positiva en el 90% de los ca<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n inmunohistoqu\u00edmica del oncogen ret\/ptc, de los reguladores de la apoptosis (bcl-2, caspasa y p-53) e indice de proliferaci\u00f3n celular ki-67 en tumores oncociticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n inmunohistoqu\u00edmica del oncogen ret\/ptc, de los reguladores de la apoptosis (bcl-2, caspasa y p-53) e indice de proliferaci\u00f3n celular ki-67 en tumores oncociticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lag Asturiano M. Encarnaci\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Villar Rodr\u00edguez Jos\u00e9 Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Loscertales abril <\/li>\n<li>Antonio Jim\u00e9nez Garc\u00eda (vocal)<\/li>\n<li>ricardo Gonzalez campora (vocal)<\/li>\n<li> Codes Manuel de villena Manuel e. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lag Asturiano M. Encarnaci\u00f3n Las neoplasias oncoc\u00edticas u oxif\u00edlicas se presentan en diversos \u00f3rganos, como gl\u00e1ndula tiroides, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10715],"tags":[1837,66941,10956,66942,11092,66943],"class_list":["post-22379","post","type-post","status-publish","format-standard","hentry","category-sevilla","tag-antonio-jimenez-garcia","tag-codes-manuel-de-villena-manuel-e","tag-jesus-loscertales-abril","tag-lag-asturiano-m-encarnacion","tag-ricardo-gonzalez-campora","tag-villar-rodriguez-jose-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22379"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22379\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22379"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22379"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}