{"id":22383,"date":"2003-02-04T00:00:00","date_gmt":"2003-02-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-p27-en-el-control-de-la-proliferacion-y-migracion-de-celulas-vasculares-implicaciones-en-fisiopatologa%c2%ada-vascular\/"},"modified":"2003-02-04T00:00:00","modified_gmt":"2003-02-04T00:00:00","slug":"papel-de-p27-en-el-control-de-la-proliferacion-y-migracion-de-celulas-vasculares-implicaciones-en-fisiopatologa%c2%ada-vascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-p27-en-el-control-de-la-proliferacion-y-migracion-de-celulas-vasculares-implicaciones-en-fisiopatologa%c2%ada-vascular\/","title":{"rendered":"Papel de p27 en el control de la proliferaci\u00f3n y migraci\u00f3n de c\u00e9lulas vasculares: implicaciones en fisiopatolog\u00eda vascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Diez Juan <\/strong><\/h2>\n<p>Hip\u00f3tesis planteadas en esta tesis i: la sobreexpresi\u00f3n de p27kip1 inhibe la migraci\u00f3n de c\u00e9lulas vasculares in vitro y el proceso de neovascularizaci\u00f3n in vivo.  hip\u00f3tesis ii: p27kip1 regula de un modo coordinado la proliferaci\u00f3n y migraci\u00f3n celular.  hip\u00f3tesis iii: p27kip1 progege contra el desarrollo del ateroma en animales hipercolesterol\u00e9micos.  con el fin de comprobar experimentalmente estas hip\u00f3tesis, nos planteamos los siguientes objetivos:  objetivo 1: investigar el efecto de la sobreexpresi\u00f3n de p27kip1 sobre la migraci\u00f3n de ces in vitro y en un modelo murino de neovascularizaci\u00f3n esperimental.  objetivo 2: investigar si el efecto antimigratorio de p27kip1 requiere su actividad antiproliferativa, o si por el contrario son dos funciones independientes.  objetivo 3: investigar el efecto de variar la dosis g\u00e9nica de p27kip1 sobre el desarrollo del ateroma en un modelo murino de arteriosclerosis experimental.  se ha concluido en esta tesis: que la inactivaci\u00f3n total de p27kip1 no es suficiente para inducir el desarrollo de ateromas si no se acompa\u00f1a de un est\u00edmulo aterog\u00e9nico (hiperlipidemia en nuestro modelo experimental). sin embargo en un entorno gen\u00e9tico de susceptibilidad a ateriosclerosis (inactivaci\u00f3n de apoe), una disminuci\u00f3n moderada en los niveles de p27kip1 acelera significativamente el proceso aterog\u00e9nico, siendo este efecto m\u00e1s patente si se inactiva totalmente p27kip1. Nuestros estudios en este modelo de arteriosclerosis experimental, junto con los resultados de nuestros estudios in vitro, sugieren que p27kip1 protege contra el desarrollo del ateroma inhibiendo los procesos de proliferaci\u00f3n y migraci\u00f3n celular en pared arterial.  estos estudios han permitido identificar la prote\u00edna p27kip1 un regulador clave de procesos implicados en la fisiopatolog\u00eda vascular, tales como la proliferaci\u00f3n y migraci\u00f3n de c\u00e9lulas vasculares. Variaciones en los niveles de expresi\u00f3n de p27 kip1 af<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de p27 en el control de la proliferaci\u00f3n y migraci\u00f3n de c\u00e9lulas vasculares: implicaciones en fisiopatolog\u00eda vascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de p27 en el control de la proliferaci\u00f3n y migraci\u00f3n de c\u00e9lulas vasculares: implicaciones en fisiopatolog\u00eda vascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Diez Juan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Andr\u00e9s Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Mu\u00f1oz terol <\/li>\n<li>lisardo Bosc\u00e1 gomar (vocal)<\/li>\n<li>guillermo Saez tormo (vocal)<\/li>\n<li>Jes\u00fas De la osada Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Diez Juan Hip\u00f3tesis planteadas en esta tesis i: la sobreexpresi\u00f3n de p27kip1 inhibe la migraci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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