{"id":22403,"date":"2003-03-04T00:00:00","date_gmt":"2003-03-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/farmacocinetica-y-farmacodinamia-de-irinotecan-en-pacientes-con-carcinoma-colorrectal-metastasico\/"},"modified":"2003-03-04T00:00:00","modified_gmt":"2003-03-04T00:00:00","slug":"farmacocinetica-y-farmacodinamia-de-irinotecan-en-pacientes-con-carcinoma-colorrectal-metastasico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/navarra\/farmacocinetica-y-farmacodinamia-de-irinotecan-en-pacientes-con-carcinoma-colorrectal-metastasico\/","title":{"rendered":"Farmacocin\u00e9tica y farmacodinamia de irinotecan en pacientes con carcinoma colorrectal metast\u00e1sico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Castellanos L\u00e1car M. Carmen <\/strong><\/h2>\n<p>Introducci\u00f3n  el tratamiento farmacol\u00f3gico del c\u00e1ncer presenta entre otras dificultades la reistencia de las c\u00e9lulas tumorales a los antineopl\u00e1sicos y el estrecho margen terap\u00e9utico de estos medicamentos, lo que obliga al cl\u00ednico a un planteamiento individualizado de la posolog\u00eda con objeto de alcanzar el m\u00e1ximo beneficio terap\u00e9utico posible con un grado de toxicidad aceptable.  los trabajos m\u00e1s actuales est\u00e1n dirigidos hacia el desarrollo de herramientas que permitan mejorar el conocimiento de la relaci\u00f3n f\u00e1rmaco-paciente. Entre ellas podemos citar la farmacocin\u00e9tica cl\u00ednica o famracocin\u00e9tica aplicada de citost\u00e1ticos.  el irinotecan es uno de los f\u00e1rmacos m\u00e1s importantes actualmente para el tratamiento del c\u00e1ncer colorrectal.  objetivo  caracterizar el comportamiento farmacocin\u00e9tico de irinotecan y sus metabolicos (sn-38 y sn-38 glucur\u00f3nido) en pacientes diagnosticados de carcinoma colorrectal metast\u00e1sico y establecer posibles relaciones entre dichos par\u00e1metros y los principales efectos adversos observados tras el tratamiento.  pacientes y m\u00e9todos  la caracterizaci\u00f3n del comportamiento farmacocin\u00e9tico de irinotecan se ha realizado ajustando los datos de concentraci\u00f3n plasm\u00e1tica-teimpo a un modelo bicompartimental lineal tanto por m\u00e9todos parame\u00c2\u00bftricos como no param\u00e9tricos. Los par\u00e1metros faramcocin\u00e9ticos de los metabolitos se han estimado mediante an\u00e1lisis no compartimental. El an\u00e1lisis de las relaciones entre ellos y los efectos adversos producidos por el tratamiento, se ha realizado mediante regresi\u00f3n lieanl y log\u00edstica.  resultados  se ha encontrado asociaci\u00f3n importante entre los par\u00e1metros farmacocin\u00e9ticos de exposici\u00f3n a irinotecan y la toxicidad hematol\u00f3gica (neutropenia) y gastrointestinal (diarrea y mucositis) producidas por el tratamiento.  conclusi\u00f3n  la farmacocin\u00e9tica contribuye a optimizar el tratamiento con irinotecan en pacientes con carcinoma colorrectal metast<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Farmacocin\u00e9tica y farmacodinamia de irinotecan en pacientes con carcinoma colorrectal metast\u00e1sico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Farmacocin\u00e9tica y farmacodinamia de irinotecan en pacientes con carcinoma colorrectal metast\u00e1sico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Castellanos L\u00e1car M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/04\/2003<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Azucena Aldaz Pastor<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: victor Jimenez torres <\/li>\n<li>Mar\u00eda Jes\u00fas Renedo omaechevarr\u00eda (vocal)<\/li>\n<li> Garc\u00eda s\u00e1nchez Mar\u00eda Jos\u00e9 (vocal)<\/li>\n<li>matilde Merino sanJuan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Castellanos L\u00e1car M. Carmen Introducci\u00f3n el tratamiento farmacol\u00f3gico del c\u00e1ncer presenta entre otras dificultades la reistencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17749],"tags":[57425,66997,66998,32145,17020,3309],"class_list":["post-22403","post","type-post","status-publish","format-standard","hentry","category-navarra","tag-azucena-aldaz-pastor","tag-castellanos-lacar-m-carmen","tag-garcia-sanchez-maria-jose","tag-maria-jesus-renedo-omaechevarria","tag-matilde-merino-sanjuan","tag-victor-jimenez-torres"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=22403"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/22403\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=22403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=22403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=22403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}